| Link type | Probability | Chain A piercings | Chain C piercings | Chain I piercings | Chain L piercings | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
|
Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
|
Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
| view details |
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Other | 19% | +55C +117C -153C -79I +152I +152I | +85A -96A | ||||||||||
Chain A Sequence |
HPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIE |
Chain A Sequence |
MKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIE |
Chain A Sequence |
YVNV |
Chain A Sequence |
YVNV |
| sequence length | 95,98,4,4 |
| structure length | 95,98,4,4 |
| publication title |
Dimer formation through domain swapping in the crystal structure of the Grb2-SH2-Ac-pYVNV complex.
pubmed doi rcsb |
| molecule tags | Hormone/growth factor |
| molecule keywords | GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 |
| source organism | Homo sapiens |
| ec nomenclature |
ec 2.7.10.1: Receptor protein-tyrosine kinase. ec 2.7.10.1: Receptor protein-tyrosine kinase. |
| pdb deposition date | 2000-10-03 |
| LinkProt deposition date | 2016-08-22 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| ACIL | PF00017 | SH2 | SH2 domain |
| ACIL | PF00018 | SH3_1 | SH3 domain |
| ACIL | PF00017 | SH2 | SH2 domain |
| ACIL | PF00018 | SH3_1 | SH3 domain |
Image from the rcsb pdb (www.rcsb.org)cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | 2-Layer Sandwich | SHC Adaptor Protein | SHC Adaptor Protein | ||
| Alpha Beta | 2-Layer Sandwich | SHC Adaptor Protein | SHC Adaptor Protein |
#chains in the LinkProt database with same CATH superfamily 1FYR BDL; 1FYR ABC; 1A81 CIJ; 1FYR BIK; 1FYR BK; 2AOA AB; 1A81 CD; 1FYR DKL; 1FYR BJK; 2H5K AB; 1FYR ACD; 2QMS ACD; 2AOB BC; 1FYR BCDJ; 1FYR BDK; 2H5K ABC; 1A81 CI; 1FYR ACDJ; 1FYR ABCK; 1FYR ABK; 1FYR DIJK; 1FYR DJL; 2H5K BC; 1A81 EK; 1FYR ABD; 1FYR ACJ; 2QMS ABD; 1FYR AIL; 1FYR CD; 1FYR ACJK; 2QMS CD; 1FYR ADIJ; 1FYR AKL; 1FYR BCDI; 1FYR ACKL; 1FYR BJL; 1A81 CJ; 1FYR CDJK; 1FYR CDIK; 1FYR AI; 1FYR ABCJ; 1FYR ABIJ; 1FYR BIJK; 1FYR ACJL; 1FYR BDIJ; 1FYR DK; 1FYR ADI; 1FYR ACIK; 1FYR ABCD; 1FYR CDL; 1FYR CIL; 1FYR BCKL; 1A81 KL; 1FYR AL; 1FYR BCD; 1FYR DJKL; 1FYR BIL; 1FYR ADJL; 1FYR CJ; 1FYR ADIL; 1FYR BL; 1FYR CDI; 1FYR AC; 1FYR BCL; 1FYR DJ; 1FYR ACIL; 1A81 AH; 1FYR BDIL; 1FYR BDJ; 2H5K AC; 1FYR CIJK; 1FYR BC; 2AOB CD; 1FYR BI; 1FYR BCIL; 1FYR BDJL; 1FYR ACDK; 1FYR DL; 1FYR AIJL; 1FYR ACI; 2AOB ACD; 1FYR ADL; 1FYR BCI; 1FYR ADKL; 1FYR CJKL; 1FYR ABDJ; 1FYR ABKL; 1FYR BDI; 1FYR CIJL; 2AOB ABCD; 1A81 EF; 1FYR ABI; 1FYR DIJ; 1FYR ACL; 1FYR DIKL; 1FYR ABIK; 1FYR ABDI; 1FYR ACIJ; 1A81 AB; 1FYR CJK; 1FYR BDJK; 1FYR BCJL; 1FYR BCIJ; 1FYR AJK; 1FYR AIJK; 1FYR CIK; 1FYR BJKL; 2AOB AD; 1FYR CDKL; 1FYR ABIL; 1FYR CI; 1FYR ABJK; 1A81 GH; 1FYR AIK; 1FYR ABDL; 1A81 AG; 1FYR ACDL; 1FYR CKL; 1FYR CJL; 1FYR BKL; 1FYR CDJ; 1FYR DJK; 2AOB AC; 1FYR AB; 2QMS AB; 2AOB ABD; 1FYR BIJL; 1FYR CL; 1FYR AJL; 1FYR BCDL; 1A81 AGH; 1FYR BDKL; 1FYR BIJ; 1FYR BJ; 1FYR AIKL; 1FYR AJ; 1FYR AJKL; 1FYR CDIL; 1FYR DIL; 1FYR ADK; 1FYR BCJ; 1FYR ABJL; 1FYR BCDK; 1FYR DI; 1FYR ADIK; 1FYR ACDI; 1FYR ABJ; 1FYR DIJL; 1FYR ACK; 1FYR AD; 1FYR ADJK; 2QMS AD; 2AOB ABC; 1FYR BIKL; 1FYR BCK; 1FYR BCJK; 1FYR BCIK; 2AOB BCD; 1FYR CIJ; 1FYR BD; 1FYR AK; 1FYR CDJL; 1FYR CDIJ; 1FYR DIK; 1FYR ABCI; 1FYR AIJ; 1FYR ADJ; 1FYR BDIK; 2AOB BD; 1FYR CIKL; 1FYR ABDK; 1FYR CDK; 1FYR ABCL; 2AOB AB; 1FYR ABL; 2QMS ABCD; 1FYR CK; #chains in the LinkProt database with same CATH topology 1FYR BDL; 1FYR ABC; 1A81 CIJ; 1FYR BIK; 1FYR BK; 2AOA AB; 1A81 CD; 1FYR DKL; 1FYR BJK; 2H5K AB; 1FYR ACD; 2QMS ACD; 2AOB BC; 1FYR BCDJ; 1FYR BDK; 2H5K ABC; 1A81 CI; 1FYR ACDJ; 1FYR ABCK; 1FYR ABK; 1FYR DIJK; 1FYR DJL; 2H5K BC; 1A81 EK; 1FYR ABD; 1FYR ACJ; 2QMS ABD; 1FYR AIL; 1FYR CD; 1FYR ACJK; 2QMS CD; 1FYR ADIJ; 1FYR AKL; 1FYR BCDI; 1FYR ACKL; 1FYR BJL; 1A81 CJ; 1FYR CDJK; 1FYR CDIK; 1FYR AI; 1FYR ABCJ; 1FYR ABIJ; 1FYR BIJK; 1FYR ACJL; 1FYR BDIJ; 1FYR DK; 1FYR ADI; 1FYR ACIK; 1FYR ABCD; 1FYR CDL; 1FYR CIL; 1FYR BCKL; 1A81 KL; 1FYR AL; 1FYR BCD; 1FYR DJKL; 1FYR BIL; 1FYR ADJL; 1FYR CJ; 1FYR ADIL; 1FYR BL; 1FYR CDI; 1FYR AC; 1FYR BCL; 1FYR DJ; 1FYR ACIL; 1A81 AH; 1FYR BDIL; 1FYR BDJ; 2H5K AC; 1FYR CIJK; 1FYR BC; 2AOB CD; 1FYR BI; 1FYR BCIL; 1FYR BDJL; 1FYR ACDK; 1FYR DL; 1FYR AIJL; 1FYR ACI; 2AOB ACD; 1FYR ADL; 1FYR BCI; 1FYR ADKL; 1FYR CJKL; 1FYR ABDJ; 1FYR ABKL; 1FYR BDI; 1FYR CIJL; 2AOB ABCD; 1A81 EF; 1FYR ABI; 1FYR DIJ; 1FYR ACL; 1FYR DIKL; 1FYR ABIK; 1FYR ABDI; 1FYR ACIJ; 1A81 AB; 1FYR CJK; 1FYR BDJK; 1FYR BCJL; 1FYR BCIJ; 1FYR AJK; 1FYR AIJK; 1FYR CIK; 1FYR BJKL; 2AOB AD; 1FYR CDKL; 1FYR ABIL; 1FYR CI; 1FYR ABJK; 1A81 GH; 1FYR AIK; 1FYR ABDL; 1A81 AG; 1FYR ACDL; 1FYR CKL; 1FYR CJL; 1FYR BKL; 1FYR CDJ; 1FYR DJK; 2AOB AC; 1FYR AB; 2QMS AB; 2AOB ABD; 1FYR BIJL; 1FYR CL; 1FYR AJL; 1FYR BCDL; 1A81 AGH; 1FYR BDKL; 1FYR BIJ; 1FYR BJ; 1FYR AIKL; 1FYR AJ; 1FYR AJKL; 1FYR CDIL; 1FYR DIL; 1FYR ADK; 1FYR BCJ; 1FYR ABJL; 1FYR BCDK; 1FYR DI; 1FYR ADIK; 1FYR ACDI; 1FYR ABJ; 1FYR DIJL; 1FYR ACK; 1FYR AD; 1FYR ADJK; 2QMS AD; 2AOB ABC; 1FYR BIKL; 1FYR BCK; 1FYR BCJK; 1FYR BCIK; 2AOB BCD; 1FYR CIJ; 1FYR BD; 1FYR AK; 1FYR CDJL; 1FYR CDIJ; 1FYR DIK; 1FYR ABCI; 1FYR AIJ; 1FYR ADJ; 1FYR BDIK; 2AOB BD; 1FYR CIKL; 1FYR ABDK; 1FYR CDK; 1FYR ABCL; 2AOB AB; 1FYR ABL; 2QMS ABCD; 1FYR CK; #chains in the LinkProt database with same CATH homology 1FYR BDL; 1FYR ABC; 1A81 CIJ; 1FYR BIK; 1FYR BK; 2AOA AB; 1A81 CD; 1FYR DKL; 1FYR BJK; 2H5K AB; 1FYR ACD; 2QMS ACD; 2AOB BC; 1FYR BCDJ; 1FYR BDK; 2H5K ABC; 1A81 CI; 1FYR ACDJ; 1FYR ABCK; 1FYR ABK; 1FYR DIJK; 1FYR DJL; 2H5K BC; 1A81 EK; 1FYR ABD; 1FYR ACJ; 2QMS ABD; 1FYR AIL; 1FYR CD; 1FYR ACJK; 2QMS CD; 1FYR ADIJ; 1FYR AKL; 1FYR BCDI; 1FYR ACKL; 1FYR BJL; 1A81 CJ; 1FYR CDJK; 1FYR CDIK; 1FYR AI; 1FYR ABCJ; 1FYR ABIJ; 1FYR BIJK; 1FYR ACJL; 1FYR BDIJ; 1FYR DK; 1FYR ADI; 1FYR ACIK; 1FYR ABCD; 1FYR CDL; 1FYR CIL; 1FYR BCKL; 1A81 KL; 1FYR AL; 1FYR BCD; 1FYR DJKL; 1FYR BIL; 1FYR ADJL; 1FYR CJ; 1FYR ADIL; 1FYR BL; 1FYR CDI; 1FYR AC; 1FYR BCL; 1FYR DJ; 1FYR ACIL; 1A81 AH; 1FYR BDIL; 1FYR BDJ; 2H5K AC; 1FYR CIJK; 1FYR BC; 2AOB CD; 1FYR BI; 1FYR BCIL; 1FYR BDJL; 1FYR ACDK; 1FYR DL; 1FYR AIJL; 1FYR ACI; 2AOB ACD; 1FYR ADL; 1FYR BCI; 1FYR ADKL; 1FYR CJKL; 1FYR ABDJ; 1FYR ABKL; 1FYR BDI; 1FYR CIJL; 2AOB ABCD; 1A81 EF; 1FYR ABI; 1FYR DIJ; 1FYR ACL; 1FYR DIKL; 1FYR ABIK; 1FYR ABDI; 1FYR ACIJ; 1A81 AB; 1FYR CJK; 1FYR BDJK; 1FYR BCJL; 1FYR BCIJ; 1FYR AJK; 1FYR AIJK; 1FYR CIK; 1FYR BJKL; 2AOB AD; 1FYR CDKL; 1FYR ABIL; 1FYR CI; 1FYR ABJK; 1A81 GH; 1FYR AIK; 1FYR ABDL; 1A81 AG; 1FYR ACDL; 1FYR CKL; 1FYR CJL; 1FYR BKL; 1FYR CDJ; 1FYR DJK; 2AOB AC; 1FYR AB; 2QMS AB; 2AOB ABD; 1FYR BIJL; 1FYR CL; 1FYR AJL; 1FYR BCDL; 1A81 AGH; 1FYR BDKL; 1FYR BIJ; 1FYR BJ; 1FYR AIKL; 1FYR AJ; 1FYR AJKL; 1FYR CDIL; 1FYR DIL; 1FYR ADK; 1FYR BCJ; 1FYR ABJL; 1FYR BCDK; 1FYR DI; 1FYR ADIK; 1FYR ACDI; 1FYR ABJ; 1FYR DIJL; 1FYR ACK; 1FYR AD; 1FYR ADJK; 2QMS AD; 2AOB ABC; 1FYR BIKL; 1FYR BCK; 1FYR BCJK; 1FYR BCIK; 2AOB BCD; 1FYR CIJ; 1FYR BD; 1FYR AK; 1FYR CDJL; 1FYR CDIJ; 1FYR DIK; 1FYR ABCI; 1FYR AIJ; 1FYR ADJ; 1FYR BDIK; 2AOB BD; 1FYR CIKL; 1FYR ABDK; 1FYR CDK; 1FYR ABCL; 2AOB AB; 1FYR ABL; 2QMS ABCD; 1FYR CK;
#similar chains in the LinkProt database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unlinked ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
