Link type | Probability | Chain A piercings | Chain B piercings | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A | |||||||||
view details | Hopf.1 | 54% | +1339B +1360B -1370B +1394B -1512B | +1511A |
Chain A Sequence |
MKLMIVGNTGSGKTTLLQQLMK-----------TVGIDVKDWPI---------LVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNF |
Chain A Sequence |
MKLMIVGNTGSGKTTLLQQLMKT-------QSATVGIDVKDWPI---------LVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNFK |
sequence length | 177,178 |
structure length | 157,162 |
publication title |
Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
pubmed doi rcsb |
molecule tags | Transferase |
molecule keywords | Leucine-rich repeat kinase 2 |
source organism | Homo sapiens |
missing residues | A: 1356-1368,1378-1388 B: 1357-1365,1378-1388 |
ec nomenclature |
ec 2.7.11.1: Non-specific serine/threonine protein kinase. ec 2.7.11.1: Non-specific serine/threonine protein kinase. |
pdb deposition date | 2007-12-13 |
LinkProt deposition date | 2016-10-29 |
chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
---|---|---|---|
AB | PF08477 | Roc | Ras of Complex, Roc, domain of DAPkinase |
AB | PF08477 | Roc | Ras of Complex, Roc, domain of DAPkinase |
cath code
| Class | Architecture | Topology | Homology | Domain |
---|---|---|---|---|---|
Alpha Beta | 2-Layer Sandwich | Alpha-Beta Plaits | ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 | ||
Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases | ||
Alpha Beta | 2-Layer Sandwich | Alpha-Beta Plaits | ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 | ||
Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | P-loop containing nucleotide triphosphate hydrolases |
#chains in the LinkProt database with same CATH superfamily 1E0J DEF; 1E0J BCD; 1E0J BCEF; 1E0J ABF; 3DO6 AB; 1E0J CD; 1E0J CEF; 1E0J EF; 1E0J ABCD; 1E0J BDEF; 1E0J BCE; 3DZD AB; 1E0J ABC; 1E0J CDEF; 1E0J AB; 1E0J ABCE; 1E0J BCF; 2IF0 AB; 2ZEJ AB; 1E0J BCDF; 1E0J CF; 1E0J BF; 1E0J CDE; 1E0J DE; 1E0J BC; 1E0J ABEF; 1E0J CE; 1E0J CDF; 1E0J BEF; 2IEY AB; 1E0J BCDE; 1E0J ABCF; #chains in the LinkProt database with same CATH topology 3ETD CEF; 3H90 BC; 3HWX AB; 1XCB ACEF; 1XCB ADEF; 3KDP ABC; 1MV8 AC; 3GYX JL; 1O5O BCD; 3N2L ABCD; 2AMF CD; 2AHR BCD; 3H3F EGH; 3ETD CD; 2AMF ABC; 3HWX 1S; 3ETG BDE; 1XCB ABEF; 3GMD CD; 3GDG AC; 3HWX IJ; 3GYX FIJ; 3GYX EGH; 3HWX BSZ; 2AHR ACE; 3GYX BD; 3GYX HIK; 3N2L EFH; 3GYX BCG; 3N2L DGH; 3N2L CEF; 1A97 BD; 2AHR ABCE; 1XCB BDEG; 2BI4 AB; 2AMF ACD; 3GYX BDI; 3GYX DEK; 1XCB BE; 3H3F ABF; 3HWX IS; 3GYX CFL; 1MUU BD; 1MV8 CD; 1E0J CEF; 3GYX ABD; 3ETD ADF; 3GYX HJ; 1XCB BCEG; 3GYX EIJ; 3N2L CDEH; 1O5O CD; 3GYX BGL; 3GMD BFG; 3GYX CDK; 3N2L ACF; 3GYX BEJ; 3N2L EH; 3F7O AB; 3N2L ADEH; 1E0J ABCF; 1E0J BCF; 3ETG AD; 1E0J BC; 2AMF ADE; 3ETG BCF; 1XCB ABG; 2AMF AD; 3GYX ADI; 3KDP ACG; 3GVP ACD; 3GYX AJK; 3H90 BCD; 1MV8 BCD; 3N2L AB; 3H3F EFG; 3H3F BCD; 3GMD CDH; 3GYX CDL; 3GYX CGJ; 3GYX BFG; 3HWX 1BJ; 3GYX EF; 1EK1 AB; 1MV8 BD; 3ETD BE; 3ETG CDF; 3ETG BE; 3GYX EHK; 1MUU AB; 1XCB ABFG; 1E0J AB; 2AMF ABCD; 3GYX EFI; 1O5O ABD; 1A97 ACD; 3H3F BFG; 2IF0 AB; 1CR6 AB; 2ZEJ AB; 3ETG DE; 3GYX AIJ; 3F7O BY; 3HWX 1JR; 3HWX AZ; 1MUU ABD; 3GYX DHI; 3N2L GH; 3EYW AB; 3GYX CJK; 3GYX FGK; 3HWX BIS; 3HGM ABC; 3N2L ACFG; 3HWX 1RZ; 1O5O BC; 1K75 AB; 1E0J DEF; 3GYX GJK; 1XCB CD; 3HWX JSZ; 3GYX FL; 3GYX BCE; 3N2L AE; 3HWX AS; 1XCB BDE; 2AMF ABDE; 3N2L ADG; 3HWX BJZ; 2AMF ABE; 3GYX FGL; 3ETD ABD; 1XCB BG; 3GYX AFK; 3N2L EG; 3H3F ABD; 3N2L ACEG; 3GYX DKL; 1EK2 AB; 3N2L ACDF; 3GYX CEF; 2AHR DE; 2AHR AB; 3GYX DEF; 3ETD BCF; 3H3F CDF; 3GYX AHK; 3N2L ABDG; 3N2L DEGH; 1XCB ACDF; 3HWX AIJ; 1XCB BEF; 3HWX SZ; 1XCB ADF; 3KDP CDG; 3GYX AD; 3HWX BJS; 3GYX AGH; 3N2L BCF; 3GYX CDI; 2AMF AE; 3H90 AD; 1XCB CEG; 2AHR ACDE; 3GYX HKL; 2AHR BD; 3GYX CIJ; 1XCB BCDE; 3GYX ABK; 1A97 ABD; 3GDG BCD; 3HWX BI; 3H5A AD; 3HWX IJZ; 3N2L EFGH; 3N2L CD; 2AMF AB; 3GYX ADK; 1MUU BCD; 1A97 ABC; 3GDG BD; 3GYX BCI; 3N2L DEF; 3HWX AIS; 3KDP ABD; 2AHR AE; 3ETG ABF; 1O5O ABC; 3ETD BDE; 3GMD BFH; 3HWX ASZ; 3GYX CGH; 3HWX BIZ; 3HWX 1AB; 1E0J BCE; 1XCB AG; 1XCB CDEG; 2AMF ABD; 3GYX ACH; 3GYX CJL; 1MFZ AB; 3ETD CDF; 3GYX GIL; 2AMF BCDE; 3N2L ABD; 3N2L CEFG; 3H5A AC; 3GYX BG; 3N2L ACE; 3GYX EFG; 3GMD BEF; 1XCB AEF; 3N2L CDF; 3HWX AJR; 1E0J BF; 3DO6 AB; 3ETD BEF; 3GYX FKL; 3H5A ACD; 3GYX DF; 3GYX GHK; 3HWX ABZ; 3GYX BH; 3GYX ABG; 3GYX HI; 1XCB AE; 3GVP BCD; 3N2L BCDG; 2AHR BDE; 3N2L DEH; 3N2L DEFH; 3N2L BC; 1E0J CF; 1E0J DE; 1XCB AB; 3GMD BDF; 1E0J BCDE; 3HWX 1BZ; 3GYX CDF; 3GYX BEI; 3ETD ABF; 3ETD DE; 3GYX CFH; 1XCB DEF; 3HWX 1RS; 3GYX ACD; 1XCB CDF; 3GYX GHL; 3GYX IJ; 3GYX CEH; 3H90 ACD; 3N2L AD; 3ETG CEF; 3ETG BCE; 1MUU ABC; 3N2L DEFG; 3DZD AB; 3HWX AJ; 3N2L CDEG; 3GYX BGH; 3GYX AB; 3ETD ACE; 3GYX AGJ; 3N2L BCD; 3GYX BEF; 3H90 AB; 2AMF CDE; 3N2L ACEH; 3EGW BC; 3N2L AEH; 2AHR CDE; 1MV8 ABD; 3GYX ABI; 3GYX DJ; 3GYX IKL; 1XCB ACG; 3N2L CEFH; 3F7O ABX; 3GYX EFL; 3H90 ABD; 3N2L BCFG; 1XCB ACE; 3N2L DFG; 3HGM AB; 3H5A BD; 3ETG ABD; 3N2L CDFG; 1XCB ABCE; 3N2L ABCE; 1XCB CDFG; 3HWX BIJ; 3H3F GH; 3HWX ISZ; 3GYX ACJ; 1E0J BDEF; 3GDG AB; 3GMD ADH; 3GYX FIK; 2AHR ACD; 3GYX BE; 3HWX IJS; 3H3F AFG; 1KAE AB; 3GVP BD; 1XCB BEFG; 3GYX BGJ; 3HWX AIZ; 3GYX BJK; 2AMF BDE; 3GYX DGI; 3GYX BKL; 3GDG ACD; 3GYX CHI; 2AMF ACE; 3GYX CJ; 3GYX GHI; 3HWX 1IZ; 2AHR ABC; 3GYX ABE; 3GYX DEI; 3N2L BCDE; 1XCB BCEF; 3HGM BD; 3GMD ABF; 3N2L AEGH; 1E0J CD; 1XCB ACFG; 3N2L FG; 1LSS AB; 3GYX DIJ; 1MV8 ABCD; 3N2L DEG; 3HWX 1AR; 1XCB ACEG; 3HWX ARZ; 3GYX BEK; 2AHR BCDE; 3GYX HJK; 3GYX CFJ; 3GYX ACF; 3GYX AHI; 1E0J ABCE; 3HWX ABS; 1LSS CD; 3GYX CEJ; 2AHR ABD; 1O5O AB; 3GYX JKL; 1MFZ CD; 1XCB ABF; 1XCB DE; 3ETD AD; 3ETG ADE; 3GYX ADF; 2AMF ACDE; 3N2L CF; 3KDP ACD; 3N2L ADE; 3HWX 1BS; 1A97 AC; 3GYX AGL; 1E0J CDF; 1O5O ACD; 1E0J BEF; 3HWX 1BI; 1MUU ACD; 1E0J BCD; 3HWX ABJ; 2AMF BD; 3GYX EIL; 1MUU AC; 1XCB CEFG; 3N2L DG; 3ECA BCD; 3GYX EFJ; 1XCB ADEG; 1W5F AB; 1MV8 AB; 1A97 AD; 1XCB ABCG; 3GYX EJK; 3H5A ABD; 3N2L EGH; 3GYX BDG; 3HWX BIR; 1XCB ABEG; 3HGM ABD; 3N2L DFGH; 3HWX BRS; 3H3F ACD; 3GYX HIJ; 2AMF ABCE; 3GYX HL; 1XCB CE; 1E0J ABEF; 2AHR ABDE; 3GYX BCF; 3H3F EFH; 3GYX EJL; 1E0J ABF; 2AHR ABCD; 1XCB BDEF; 1XCB AFG; 1CQZ AB; 3GYX BEL; 1E0J EF; 3N2L EF; 3HWX IRS; 3GYX CD; 3GMD BCF; 3N2L ACEF; 3N2L ABEG; 3N2L ACDG; 3GYX ABC; 3GYX DEG; 3ETD BCE; 3N2L DE; 3GMD BF; 3HGM AD; 3GYX FJK; 3GMD DH; 3N2L ADGH; 3HWX AI; 1XCB ACDE; 3N2L ABEH; 3GMD DFH; 3GVP CD; 3GYX BGK; 1LSU AB; 3GYX CDJ; 3N2L CDGH; 1XCB ADFG; 3HWX 1AJ; 3GYX EL; 3GYX BHK; 3HWX IRZ; 3FDS AC; 3N2L BCDF; 3GYX CEL; 2AMF BC; 3GYX ABL; 3GYX DI; 1O5O AD; 3GYX IJL; 1XCB ABDF; 3GYX IJK; 1ATI AB; 3ETD AF; 2AMF AC; 3GYX ADH; 3GDG ABC; 3KDP ABG; 2AHR AD; 3N2L AC; 3HWX ARS; 3HWX ABR; 3HWX RSZ; 3N2L CFGH; 1XCB CDEF; 3ETD BF; 3HWX 1IJ; 3ETD CDE; 3GYX EGL; 3N2L ABE; 3N2L ACD; 3GYX EFH; 1XCB AEG; 3GDG ABD; 3N2L CDG; 3N2L ABDE; 1MUU CD; 3HGM BCD; 2AMF DE; 3EGW ABC; 3GYX HIL; 3GYX BDE; 3H3F EF; 3N2L ADEG; 3KDP AB; 1XCB CG; 3GYX DEL; 3GMD DEH; 3GYX FK; 2A6M AB; 1O5O ABCD; 3GYX BCD; 1A97 AB; 3KDP CD; 3HWX AR; 1A97 BC; 1XCB CDE; 3ETG CF; 3GYX AEF; 3N2L ADFG; 1A97 BCD; 3GYX CDG; 1KAH AB; 1E0J BCDF; 3HGM CD; 3ETD ABE; 3N2L CFG; 3HWX RZ; 3GYX CFI; 3GYX CF; 3GYX AHL; 3GYX CIL; 3HWX BRZ; 3N2L ACDE; 1MV8 ACD; 3ETD ADE; 3GYX GL; 3HWX BS; 2AMF BCD; 1XCB AEFG; 2BL4 AB; 1XCB DF; 3ETD AC; 3GYX ADE; 1XCB ACDG; 1E0J BCEF; 3ETG AEF; 3GYX AFG; 1XCB BEG; 3GMD BDH; 2AHR AC; 3GYX CKL; 1XCB EF; 3ETD ACF; 3N2L AEFH; 1XCB BCE; 3GYX CDH; 3GYX BEG; 3H90 AC; 1XCB CEF; 3DL2 AB; 2AHR ADE; 3GYX BHI; 2AHR BC; 3H3F FGH; 1MV8 ABC; 3GYX ABJ; 3HWX BJ; 3HGM ACD; 3N2L CDEF; 3F7O ABY; 3GYX KL; 3GYX GKL; 3GYX ADJ; 3GYX AKL; 1XCB BCDG; 3N2L ABEF; 3GDG BC; 3HWX BJR; 3HWX 1A; 3ECA ACD; 3HWX AIR; 3FDS ACD; 3N2L EFG; 3ETG ABE; 3GYX AEH; 3N2L ABCF; 1XCB AF; 3GYX CFG; 3GYX BIJ; 3N2L ADEF; 3KDP BCH; 1XCB ABDE; 3ETG BF; 1O5O BD; 3HWX 1IR; 3N2L ABC; 3GYX BF; 3HWX IJR; 3GYX GIJ; 1KAR AB; 3H3F BEF; 1MUU ABCD; 3H90 BD; 2IEY AB; 3N2L CDE; 3HWX AJS; 1E0J CDEF; 1E0J ABC; 3KDP CDH; 3HWX 1AZ; 3N2L FGH; 3GYX FGH; 3GDG AD; 3N2L AEG; 3GYX GHJ; 3HWX 1JS; 1X7D AB; 3GYX ABF; 3GYX GJL; 3N2L AEFG; 3GYX BGI; 3H90 ABC; 3HWX AJZ; 3GYX EKL; 1E0J CE; 3GDG CD; 3GYX DGH; 3GYX DIK; 3GMD DGH; 3GYX CDE; 3GYX BEH; 3HWX 1AI; 3GYX AFH; 3GYX CFK; 3HWX 1SZ; 1XCB CDG; 1E0J ABCD; 3HWX 1JZ; 2AHR ABE; 1O5O AC; 3ETG BCD; 3N2L BCEF; 3GYX EHI; 1XCB ABE; 3ETG ADF; 3GYX ADG; 3ETG ACF; 3N2L AEF; 3GYX DIL; 3KDP ABH; 1XCB ADE; 3GYX JK; 3HWX 1BR; 3ETD ACD; 1XCB BCG; 3GYX CGL; 1E0J CDE; 3ETG ACD; 3HWX RS; 3HWX 1Z; 3GYX ACL; 3HWX ABI; 3KDP BCG; 3GYX ABH; 3GYX GH; 3HWX JRS; 2AHR CD; 3EGW AB; 3GYX EFK; #chains in the LinkProt database with same CATH homology 1E0J DEF; 1E0J BCD; 1E0J BCEF; 1E0J ABF; 3DO6 AB; 1E0J CD; 1E0J CEF; 1E0J EF; 1E0J ABCD; 1E0J BDEF; 1E0J BCE; 3DZD AB; 1E0J ABC; 1E0J CDEF; 1E0J AB; 1E0J ABCE; 1E0J BCF; 2IF0 AB; 2ZEJ AB; 1E0J BCDF; 1E0J CF; 1E0J BF; 1E0J CDE; 1E0J DE; 1E0J BC; 1E0J ABEF; 1E0J CE; 1E0J CDF; 1E0J BEF; 2IEY AB; 1E0J BCDE; 1E0J ABCF;
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