| Link type | Probability | Chain B piercings | Chain C piercings | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
| view details |
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Hopf.1 | 68% | +169C +217C -257C | +190B | ||||||||
Chain B Sequence |
AMKIGIIGVGKMASAIIKGLKQTPHELIISGSSLERSKEIAEQLALPYAMSHQDLIDQVDLVILGIKPQLFETVLKPLHFKQPIISMAAGISLQRLATFVGQDLPLLRIMPNMNAQILQSSTALTGNALVSQELQARVRDLTDSFGSTFDISEKDFDTFTALAGSSPAYIYLFIEALAKAGVKNGIPKAKALEIVTQTVLASASNLKTSSQSPHDFIDAICSPGGTTIAGLMELERLGLTATVSSAIDKTIDKAKSL |
Chain B Sequence |
MKIGIIGVGKMASAIIKGLKQTPHELIISGSSLERSKEIAEQLALPYAMSHQDLIDQVDLVILGIKPQLFETVLKPLHFKQPIISMAAGISLQRLATFVGQDLPLLRIMPNMNAQILQSSTALTGNALVSQELQARVRDLTDSFGSTFDISEKDFDTFTALAGSSPAYIYLFIEALAKAGVKNGIPKAKALEIVTQTVLASASNLKTSSQSPHDFIDAICSPGGTTIAGLMELERLGLTATVSSAIDKTIDKAKSL |
| sequence length | 257,256 |
| structure length | 257,256 |
| publication title |
Crystal Structures of Delta(1)-Pyrroline-5-carboxylate Reductase from Human Pathogens Neisseria meningitides and Streptococcus pyogenes
pubmed doi rcsb |
| molecule tags | Oxidoreductase |
| molecule keywords | 1-Pyrroline-5-Carboxylate reductase |
| source organism | Streptococcus pyogenes |
| ec nomenclature |
ec 1.2.1.5: Aldehyde dehydrogenase (NAD(P)(+)). ec 1.2.1.5: Aldehyde dehydrogenase (NAD(P)(+)). |
| pdb deposition date | 2005-08-09 |
| LinkProt deposition date | 2016-10-22 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| BC | PF03807 | F420_oxidored | NADP oxidoreductase coenzyme F420-dependent |
| BC | PF14748 | P5CR_dimer | Pyrroline-5-carboxylate reductase dimerisation |
| BC | PF03807 | F420_oxidored | NADP oxidoreductase coenzyme F420-dependent |
| BC | PF14748 | P5CR_dimer | Pyrroline-5-carboxylate reductase dimerisation |
Image from the rcsb pdb (www.rcsb.org)cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Orthogonal Bundle | ProC C-terminal domain-like fold | ProC C-terminal domain-like | ||
| Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain | ||
| Mainly Alpha | Orthogonal Bundle | ProC C-terminal domain-like fold | ProC C-terminal domain-like | ||
| Alpha Beta | 3-Layer(aba) Sandwich | Rossmann fold | NAD(P)-binding Rossmann-like Domain |
#chains in the LinkProt database with same CATH superfamily 3ETD CEF; 1XCB CEG; 3GMD ABF; 3H3F EF; 2AHR BD; 1XCB ACEF; 1XCB ADEF; 3ETD ABE; 1XCB BCDE; 1MV8 AC; 1LSS AB; 3GDG BCD; 1MV8 ABCD; 2AMF CD; 2AHR BCD; 3H5A AD; 3H3F EGH; 2AMF ABCE; 2AHR BCDE; 2AMF AB; 1MV8 ABC; 1MUU BCD; 3ETG BDE; 3GDG BD; 3GVP BD; 3GDG AC; 2AHR ACDE; 1LSS CD; 2AHR ABCD; 2AHR AE; 3ETD BDE; 2AHR ACE; 3GMD BFH; 1XCB ABG; 1XCB CDEF; 1XCB ADF; 1MFZ CD; 1XCB ABF; 1MUU CD; 2AMF DE; 2AMF ABD; 2AMF ACDE; 1MFZ AB; 3ETD CDF; 3ETG ADE; 1XCB CDE; 1XCB ACFG; 1MV8 ACD; 1XCB ABDE; 2AMF BCDE; 3GMD BEF; 2AHR ABCE; 3H5A AC; 3ETD BF; 2AMF BCD; 1XCB BDEG; 1XCB AEFG; 2AMF ACD; 1MUU ACD; 3ETD CD; 3ETD ADE; 1XCB AEF; 1XCB BE; 3H3F ABF; 1XCB ACDG; 2AMF BD; 1MUU BD; 1XCB BEG; 3GMD BDH; 1MV8 CD; 3ETD BEF; 2AHR AC; 1MUU AC; 1XCB EF; 3ETD ADF; 3ETD ACF; 1XCB BCE; 1XCB ACEG; 1XCB BCEG; 3H5A ACD; 3ETG ABE; 3ETG ACF; 1XCB CEF; 3DL2 AB; 2AHR ADE; 2AHR BC; 1XCB ADEG; 3H3F FGH; 1MV8 AB; 3ETG ABF; 1XCB ABCG; 3H5A ABD; 3GMD BFG; 2AHR DE; 1XCB BEFG; 2AHR BDE; 3GDG BC; 1XCB ABEG; 3GMD CD; 1XCB AB; 3GMD BDF; 3H3F ACD; 1MUU ABD; 3GMD DEH; 3ETG ABD; 3ETG BCF; 2AHR ABDE; 3ETD AC; 1XCB CDEG; 3ETD ABF; 2AMF AD; 1XCB DEF; 1XCB CDF; 3GVP ACD; 3H3F EFH; 3ETG BF; 1MV8 BCD; 3H3F EFG; 3H3F BCD; 3GMD CDH; 3ETG CEF; 1XCB BDEF; 3ETG BCE; 3H3F BEF; 1MUU ABCD; 1MV8 BD; 3ETD BE; 3ETG CDF; 3GMD BCF; 3ETG BE; 1MUU AB; 1XCB ABFG; 3ETD ACE; 1XCB ABEF; 3ETG AEF; 3ETD BCE; 3ETD DE; 3ETG AD; 3GMD BF; 3H3F BFG; 2AMF CDE; 3GMD DH; 3GDG AD; 1XCB ACDE; 2AHR CDE; 1MV8 ABD; 1X7D AB; 3GMD DFH; 3GVP CD; 1XCB ACG; 1LSU AB; 1XCB ADFG; 1XCB ACE; 1XCB AFG; 1XCB BCDG; 3H5A BD; 2AHR ABD; 3GDG CD; 2AMF BC; 1XCB CEFG; 2AMF ADE; 1XCB ABCE; 1XCB ABDF; 1XCB CDFG; 3GMD DGH; 1XCB CD; 3H3F GH; 2AMF ABCD; 3ETD AF; 2AMF AC; 1XCB BCEF; 1XCB AF; 1XCB CDG; 3GDG AB; 3GMD ADH; 2AHR ABE; 3GDG ABC; 2AMF ABDE; 2AHR ACD; 3ETG CF; 3H3F AFG; 2AMF ABE; 1XCB CG; 3ETG BCD; 2AHR AB; 1XCB ABE; 3ETD ABD; 3ETG ADF; 1XCB BG; 1XCB CE; 3H3F ABD; 3ETD CDE; 1MUU ABC; 2AHR AD; 2AMF BDE; 1XCB ADE; 3GVP BCD; 3ETG DE; 3ETD ACD; 3GDG ACD; 1XCB AE; 1XCB BCG; 1XCB BDE; 3ETD BCF; 3H3F CDF; 3ETG ACD; 2AMF ACE; 1XCB AEG; 1XCB DF; 3GDG ABD; 1XCB AG; 1XCB ACDF; 1XCB DE; 2AMF ABC; 2AHR ABC; 1XCB BEF; 3ETD AD; 2AHR CD; 2AMF AE; #chains in the LinkProt database with same CATH topology 3ETD CEF; 3ETG BDE; 3HWX AB; 1XCB ACEF; 1XCB ADEF; 3KDP ABC; 1MV8 AC; 3N2L ABCD; 2AMF CD; 2AHR BCD; 3H3F EGH; 3ETD CD; 2AMF ABC; 3HWX 1S; 1XCB ABEF; 3GDG AC; 3HWX IJ; 1XCB ABDF; 3HWX ABZ; 3HWX BSZ; 2AHR ACE; 3N2L EFH; 3N2L DGH; 3N2L CEF; 1A97 BD; 2AHR ABCE; 1XCB BDEG; 2AMF ACD; 1E0J BCDE; 1XCB BE; 3H3F ABF; 3HWX IS; 1MUU BD; 1MV8 CD; 3ETD ADF; 1XCB BCEG; 3N2L CDEH; 1O5O CD; 3GMD BFG; 3N2L ACF; 3N2L EH; 3F7O AB; 3N2L ADEH; 1E0J ABCF; 3ETG AD; 1E0J BC; 2AMF ADE; 3ETG BCF; 1XCB ABG; 2AMF AD; 3KDP ACG; 3GVP ACD; 1MV8 BCD; 3N2L AB; 3H3F EFG; 3H3F BCD; 3GMD CDH; 3HWX 1BJ; 1XCB AE; 1EK1 AB; 1MV8 BD; 3ETD BE; 3ETG CDF; 1O5O BD; 1MUU AB; 1XCB ABFG; 1E0J AB; 3HWX JSZ; 1O5O ABD; 1A97 ACD; 3H3F BFG; 2IF0 AB; 1CR6 AB; 2ZEJ AB; 3HWX 1BR; 1ATI AB; 3HWX AZ; 3N2L GH; 3EYW AB; 2BI4 AB; 3HWX BIS; 3HGM ABC; 3N2L ACFG; 3HWX 1RZ; 1O5O BC; 1K75 AB; 1E0J DEF; 1XCB CD; 2AMF ABCD; 3N2L AE; 3HWX AS; 1XCB BDE; 2AMF ABDE; 3HWX BJZ; 3ETD ABD; 1XCB BG; 3N2L EG; 3H3F ABD; 3N2L ACEG; 1EK2 AB; 3N2L ACDF; 2AHR DE; 1E0J BF; 3H3F CDF; 3N2L ABDG; 3N2L DEGH; 1XCB ACDF; 3HWX AIJ; 1XCB BEF; 3HWX SZ; 2AHR AB; 3KDP CDG; 3HWX BJS; 3N2L BCF; 2AMF AE; 1XCB CEG; 2AHR BD; 1A97 ABD; 3GDG BCD; 3HWX BI; 3H5A AD; 3HWX IJZ; 3N2L EFGH; 3N2L CD; 2AMF AB; 1MUU BCD; 3N2L ABEG; 3GDG BD; 3HGM AD; 3N2L DEF; 2AHR ACDE; 3KDP ABD; 2AHR AE; 1O5O ABC; 3ETD BDE; 3GMD BFH; 3HWX ASZ; 3HWX BIZ; 3HWX 1AB; 1E0J BCE; 1XCB AG; 2AMF DE; 2AMF ABD; 3N2L ADEG; 1MFZ AB; 3ETD CDF; 1XCB ABDE; 2AMF BCDE; 3N2L ABD; 3N2L CEFG; 3H5A AC; 1E0J BCF; 3N2L ACE; 3ETG BCE; 3GMD BEF; 1XCB AEF; 3N2L CDF; 3HWX AJR; 3DO6 AB; 3ETD BEF; 3H5A ACD; 3HWX 1JR; 3N2L BCDG; 2AHR BDE; 3N2L DEH; 3N2L DEFH; 3N2L BC; 1E0J CF; 1E0J DE; 1XCB AB; 3GMD BDF; 1MUU ABD; 3HWX 1BZ; 3ETD ABF; 3ETD DE; 1XCB DEF; 3HWX 1RS; 1XCB CDF; 3ETD BCF; 1XCB BCDE; 1A97 ABC; 3N2L AD; 3ETG CEF; 1O5O BCD; 3N2L DEFG; 3DZD AB; 3HWX AJ; 3N2L CDEG; 1MUU ABC; 3ETD ACE; 3N2L BCD; 2AMF CDE; 3N2L ACEH; 3N2L AEH; 2AHR CDE; 1MV8 ABD; 1XCB ACG; 3N2L CEFH; 3F7O ABX; 3N2L CF; 3N2L BCFG; 1XCB ACE; 3N2L DFG; 3HGM AB; 3H5A BD; 3ETG ABD; 3N2L CDFG; 1XCB ABCE; 3N2L ABCE; 1XCB CDFG; 3HWX BIJ; 3H3F GH; 3HWX ISZ; 1E0J BDEF; 3GDG AB; 3GMD ADH; 2AHR ACD; 3HWX IJS; 3H3F AFG; 1XCB CG; 3GVP BD; 3GDG AD; 3HWX AIZ; 2AMF BDE; 3ECA ACD; 3GDG ACD; 2AMF ACE; 3HWX 1IZ; 2AHR ABC; 3N2L BCDE; 2AHR CD; 3HGM BD; 3GMD ABF; 3N2L AEGH; 1E0J CD; 1XCB ACFG; 3N2L FG; 1LSS AB; 1E0J CEF; 1MV8 ABCD; 3N2L DEG; 3HWX 1AR; 1XCB ACEG; 3HWX ARZ; 2AHR BCDE; 1E0J ABCE; 3HWX ABS; 1LSS CD; 1XCB BCDG; 2AHR ABD; 1O5O AB; 1A97 AD; 1XCB ADF; 1MFZ CD; 1XCB ABF; 1XCB DE; 3ETD AD; 3ETG ADE; 2AMF ACDE; 3KDP ACD; 3N2L ADE; 3HWX 1BS; 1A97 AC; 1E0J CDF; 1O5O ACD; 1E0J BEF; 3HWX 1BI; 1MUU ACD; 1E0J BCD; 3HWX ABJ; 2AMF BD; 1MUU AC; 1XCB CEFG; 3N2L DG; 3ECA BCD; 1XCB ADEG; 1W5F AB; 1MV8 AB; 3ETG ABF; 1XCB ABCG; 3H5A ABD; 3N2L EGH; 3HWX BIR; 1XCB ABEG; 3HGM ABD; 3N2L DFGH; 3HWX BRS; 3H3F ACD; 3GMD DEH; 1XCB CE; 1E0J ABEF; 2AHR ABDE; 3H3F EFH; 1E0J ABF; 2AHR ABCD; 1XCB BDEF; 1XCB AFG; 1CQZ AB; 1E0J EF; 3N2L EF; 3HWX IRS; 3HWX 1A; 3GMD BCF; 3N2L ACEF; 3N2L ACDG; 2IEY AB; 3ETD BCE; 3N2L DE; 3GMD BF; 3GMD DH; 3HWX AI; 1XCB ACDE; 3N2L ABEH; 3GMD DFH; 3GVP CD; 3HWX AIS; 1LSU AB; 3N2L CDGH; 1XCB ADFG; 3HWX 1AJ; 3HWX IRZ; 2AMF BC; 1O5O AD; 3F7O BY; 3ETD AF; 2AMF AC; 3GDG ABC; 3KDP ABG; 2AHR AD; 3N2L AC; 3HWX ARS; 3HWX 1JZ; 3HWX RSZ; 3N2L CFGH; 1XCB CDEF; 3ETD BF; 3HWX 1IJ; 3ETD CDE; 3GVP BCD; 3N2L ABE; 3N2L ACD; 1XCB AEG; 3GDG ABD; 3N2L CDG; 3N2L ABDE; 1MUU CD; 3HGM BCD; 1XCB CDEG; 3H3F EF; 3KDP AB; 2AMF ABCE; 3N2L BCDF; 1O5O ABCD; 1A97 AB; 3KDP CD; 3HWX AR; 1A97 BC; 3ETG CF; 3N2L ADFG; 1A97 BCD; 1KAH AB; 1E0J BCDF; 3ETD ABE; 3HWX RZ; 1XCB CDE; 3HGM CD; 3HWX BRZ; 3N2L ACDE; 1MV8 ACD; 3ETD ADE; 3HWX BS; 2AMF BCD; 1XCB AEFG; 2BL4 AB; 1XCB DF; 3ETD AC; 1XCB ACDG; 1E0J BCEF; 3ETG AEF; 1XCB BEG; 3GMD BDH; 2AHR AC; 1XCB EF; 3HWX BJR; 3N2L AEFH; 1XCB BCE; 3ETG ACF; 1XCB CEF; 3DL2 AB; 2AHR ADE; 2AHR BC; 3H3F FGH; 1MV8 ABC; 3HWX BJ; 3HGM ACD; 3N2L CDEF; 3F7O ABY; 3N2L ABEF; 3GDG BC; 3GMD CD; 3HWX AIR; 3N2L EFG; 3ETG ABE; 3N2L ABCF; 1XCB AF; 3N2L ADG; 2AMF ABE; 3N2L ADEF; 3KDP BCH; 3ETG BF; 3ETG BE; 3HWX 1IR; 3N2L ABC; 3HWX IJR; 3H3F BEF; 1MUU ABCD; 3N2L CDE; 3HWX AJS; 1E0J CDEF; 1E0J ABC; 3KDP CDH; 3HWX 1AZ; 3N2L FGH; 1XCB BEFG; 3N2L AEG; 3HWX 1JS; 1X7D AB; 3N2L AEFG; 1KAR AB; 3HWX AJZ; 1E0J CE; 3GDG CD; 3ETD ACF; 3GMD DGH; 3KDP BCG; 3N2L ADGH; 3HWX 1AI; 3HWX 1SZ; 1XCB CDG; 1E0J ABCD; 3HWX ABR; 2AHR ABE; 1O5O AC; 3ETG BCD; 3N2L BCEF; 1XCB ABE; 3ETG ADF; 3N2L CFG; 3N2L AEF; 3KDP ABH; 1XCB ADE; 3ETG DE; 3ETD ACD; 1XCB BCG; 1E0J CDE; 3ETG ACD; 3HWX RS; 3HWX 1Z; 3HWX ABI; 1KAE AB; 3HWX JRS; 1XCB BCEF; #chains in the LinkProt database with same CATH homology 3ETD CEF; 1XCB CEG; 3GMD ABF; 3H3F EF; 2AHR BD; 1XCB ACEF; 1XCB ADEF; 3ETD ABE; 1XCB BCDE; 1MV8 AC; 1LSS AB; 3GDG BCD; 1MV8 ABCD; 2AMF CD; 2AHR BCD; 3H5A AD; 3H3F EGH; 2AMF ABCE; 2AHR BCDE; 2AMF AB; 1MV8 ABC; 1MUU BCD; 3ETG BDE; 3GDG BD; 3GVP BD; 3GDG AC; 2AHR ACDE; 1LSS CD; 2AHR ABCD; 2AHR AE; 3ETD BDE; 2AHR ACE; 3GMD BFH; 1XCB ABG; 1XCB CDEF; 1XCB ADF; 1MFZ CD; 1XCB ABF; 1MUU CD; 2AMF DE; 2AMF ABD; 2AMF ACDE; 1MFZ AB; 3ETD CDF; 3ETG ADE; 1XCB CDE; 1XCB ACFG; 1MV8 ACD; 1XCB ABDE; 2AMF BCDE; 3GMD BEF; 2AHR ABCE; 3H5A AC; 3ETD BF; 2AMF BCD; 1XCB BDEG; 1XCB AEFG; 2AMF ACD; 1MUU ACD; 3ETD CD; 3ETD ADE; 1XCB AEF; 1XCB BE; 3H3F ABF; 1XCB ACDG; 2AMF BD; 1MUU BD; 1XCB BEG; 3GMD BDH; 1MV8 CD; 3ETD BEF; 2AHR AC; 1MUU AC; 1XCB EF; 3ETD ADF; 3ETD ACF; 1XCB BCE; 1XCB ACEG; 1XCB BCEG; 3H5A ACD; 3ETG ABE; 3ETG ACF; 1XCB CEF; 3DL2 AB; 2AHR ADE; 2AHR BC; 1XCB ADEG; 3H3F FGH; 1MV8 AB; 3ETG ABF; 1XCB ABCG; 3H5A ABD; 3GMD BFG; 2AHR DE; 1XCB BEFG; 2AHR BDE; 3GDG BC; 1XCB ABEG; 3GMD CD; 1XCB AB; 3GMD BDF; 3H3F ACD; 1MUU ABD; 3GMD DEH; 3ETG ABD; 3ETG BCF; 2AHR ABDE; 3ETD AC; 1XCB CDEG; 3ETD ABF; 2AMF AD; 1XCB DEF; 1XCB CDF; 3GVP ACD; 3H3F EFH; 3ETG BF; 1MV8 BCD; 3H3F EFG; 3H3F BCD; 3GMD CDH; 3ETG CEF; 1XCB BDEF; 3ETG BCE; 3H3F BEF; 1MUU ABCD; 1MV8 BD; 3ETD BE; 3ETG CDF; 3GMD BCF; 3ETG BE; 1MUU AB; 1XCB ABFG; 3ETD ACE; 1XCB ABEF; 3ETG AEF; 3ETD BCE; 3ETD DE; 3ETG AD; 3GMD BF; 3H3F BFG; 2AMF CDE; 3GMD DH; 3GDG AD; 1XCB ACDE; 2AHR CDE; 1MV8 ABD; 1X7D AB; 3GMD DFH; 3GVP CD; 1XCB ACG; 1LSU AB; 1XCB ADFG; 1XCB ACE; 1XCB AFG; 1XCB BCDG; 3H5A BD; 2AHR ABD; 3GDG CD; 2AMF BC; 1XCB CEFG; 2AMF ADE; 1XCB ABCE; 1XCB ABDF; 1XCB CDFG; 3GMD DGH; 1XCB CD; 3H3F GH; 2AMF ABCD; 3ETD AF; 2AMF AC; 1XCB BCEF; 1XCB AF; 1XCB CDG; 3GDG AB; 3GMD ADH; 2AHR ABE; 3GDG ABC; 2AMF ABDE; 2AHR ACD; 3ETG CF; 3H3F AFG; 2AMF ABE; 1XCB CG; 3ETG BCD; 2AHR AB; 1XCB ABE; 3ETD ABD; 3ETG ADF; 1XCB BG; 1XCB CE; 3H3F ABD; 3ETD CDE; 1MUU ABC; 2AHR AD; 2AMF BDE; 1XCB ADE; 3GVP BCD; 3ETG DE; 3ETD ACD; 3GDG ACD; 1XCB AE; 1XCB BCG; 1XCB BDE; 3ETD BCF; 3H3F CDF; 3ETG ACD; 2AMF ACE; 1XCB AEG; 1XCB DF; 3GDG ABD; 1XCB AG; 1XCB ACDF; 1XCB DE; 2AMF ABC; 2AHR ABC; 1XCB BEF; 3ETD AD; 2AHR CD; 2AMF AE;
#similar chains in the LinkProt database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unlinked ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
