1Y8NAB

Crystal structure of the pdk3-l2 complex
A: 306-320,321-324 B: 220-226
Link type Probability Chain A piercings Chain B piercings
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
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Unlink Unlink 77% +153A -372A
Interpreting sequences
Chain A Sequence
PKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYS-------------PL--FGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASK
Chain A Sequence
SYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCIIVEKEADISAFADY-----TDLK
sequence length 389,102
structure length 374,97
publication title Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.
pubmed doi rcsb
molecule tags Transferase
molecule keywords [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3
source organism Homo sapiens
missing residues A: 306-320,321-324 B: 220-226
ec nomenclature ec 2.7.11.2: [Pyruvate dehydrogenase (acetyl-transferring)] kinase.
ec 2.3.1.12: Dihydrolipoyllysine-residue acetyltransferase.
pdb deposition date2004-12-13
LinkProt deposition date2016-10-22

pfam database annotations

chain Pfam Accession CodePfam Family IdentifierPfam Description
AB PF02518 HATPase_cHistidine kinase-, DNA gyrase B-, and HSP90-like ATPase
AB PF10436 BCDHK_Adom3Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase
AB PF00364 Biotin_lipoylBiotin-requiring enzyme
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.20.140.20 Mainly Alpha Up-down Bundle Butyryl-CoA Dehydrogenase, subunit A; domain 3 Butyryl-CoA Dehydrogenase, subunit A; domain 3 1y8nA01
3.30.565.10 Alpha Beta 2-Layer Sandwich Heat Shock Protein 90 Heat Shock Protein 90 1y8nA02
2.40.50.100 Mainly Beta Beta Barrel OB fold (Dihydrolipoamide Acetyltransferase, E2P) OB fold (Dihydrolipoamide Acetyltransferase, E2P) 1y8nB00
1Y8PAB 1Y8NAB 1Y8OAB
chains in the LinkProt database with same CATH superfamily
1ASYAB 1Y8PAB 1Y8NAB 1ASZAB 1Y8OAB 1SNDAB
chains in the LinkProt database with same CATH topology
1Y8PAB 1Y8NAB 1Y8OAB 1SNDAB
chains in the LinkProt database with same CATH homology


 
#chains in the LinkProt database with same CATH superfamily
 1Y8P AB;  1Y8N AB;  1Y8O AB; 
#chains in the LinkProt database with same CATH topology
 1ASY AB;  1Y8P AB;  1Y8N AB;  1ASZ AB;  1Y8O AB;  1SND AB; 
#chains in the LinkProt database with same CATH homology
 1Y8P AB;  1Y8N AB;  1Y8O AB;  1SND AB; 
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#similar chains in the LinkProt database (?% sequence similarity)
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#similar chains, but unlinked
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#similar chains in the pdb database (?% sequence similarity)
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LinkProt | Interdisciplinary Laboratory of Biological Systems Modelling