| Link type | Probability | Chain A piercings | Chain B piercings | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| view details |
 |
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
| view details |
|
Unlink | 77% | +153A -372A | |||||||||
Chain A Sequence |
PKQIERYSRFSPSPLSIKQFLDFGRDNACEKTSYMFLRKELPVRLANTMREVNLLPDNLLNRPSVGLVQSWYMQSFLELLEYENKSPEDPQVLDNFLQVLIKVRNRHNDVVPTMAQGVIEYKEKFGFDPFISTNIQYFLDRFYTNRISFRMLINQHTLLFGGDTNPVHPKHIGSIDPTCNVADVVKDAYETAKMLCEQYYLVAPELEVEEFNAKAPDKPIQVVYVPSHLFHMLFELFKNSMRATVELYEDRKEGYPAVKTLVTLGKEDLSIKISDLGGGVPLRKIDRLFNYMYS-------------PL--FGYGLPISRLYARYFQGDLKLYSMEGVGTDAVIYLKALSSESFERLPVFNKSAWRHYKTTPEADDWSNPSSEPRDASK |
Chain A Sequence |
SYPPHMQVLLPALSPTMTMGTVQRWEKKVGEKLSEGDLLAEIETDKATIGFEVQEEGYLAKILVPEGTRDVPLGTPLCIIVEKEADISAFADY-----TDLK |
| sequence length | 389,102 |
| structure length | 374,97 |
| publication title |
Crystal structure of pyruvate dehydrogenase kinase 3 bound to lipoyl domain 2 of human pyruvate dehydrogenase complex.
pubmed doi rcsb |
| molecule tags | Transferase |
| molecule keywords | [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 3 |
| source organism | Homo sapiens |
| missing residues | A: 306-320,321-324 B: 220-226 |
| ec nomenclature |
ec 2.7.11.2: [Pyruvate dehydrogenase (acetyl-transferring)] kinase. ec 2.3.1.12: Dihydrolipoyllysine-residue acetyltransferase. |
| pdb deposition date | 2004-12-13 |
| LinkProt deposition date | 2016-10-22 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| AB | PF02518 | HATPase_c | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase |
| AB | PF10436 | BCDHK_Adom3 | Mitochondrial branched-chain alpha-ketoacid dehydrogenase kinase |
| AB | PF00364 | Biotin_lipoyl | Biotin-requiring enzyme |
Image from the rcsb pdb (www.rcsb.org)cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Alpha | Up-down Bundle | Butyryl-CoA Dehydrogenase, subunit A; domain 3 | Butyryl-CoA Dehydrogenase, subunit A; domain 3 | ||
| Alpha Beta | 2-Layer Sandwich | Heat Shock Protein 90 | Heat Shock Protein 90 | ||
| Mainly Beta | Beta Barrel | OB fold (Dihydrolipoamide Acetyltransferase, E2P) | OB fold (Dihydrolipoamide Acetyltransferase, E2P) |
#chains in the LinkProt database with same CATH superfamily 1Y8P AB; 1Y8N AB; 1Y8O AB; #chains in the LinkProt database with same CATH topology 1ASY AB; 1Y8P AB; 1Y8N AB; 1ASZ AB; 1Y8O AB; 1SND AB; #chains in the LinkProt database with same CATH homology 1Y8P AB; 1Y8N AB; 1Y8O AB; 1SND AB;
#similar chains in the LinkProt database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unlinked ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
