| Link type | Probability | Chain E piercings | Chain F piercings | Chain G piercings | Chain H piercings | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| view details |
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Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
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Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
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Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
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Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
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Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
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Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
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Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
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Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
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Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
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Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
| view details |
|
Other | 49% | +27G -45G +62H -75H -100H | -121E -15G +29G -53G -101G +57H -112H -120H -120H | -120H | |||||||||
Chain E Sequence |
GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA |
Chain E Sequence |
GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA |
Chain E Sequence |
GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA |
Chain E Sequence |
GGPMDASVEEEGVRRALDFAVGEYNKASNDMYHSRALQVVRARKQIVAGVNYFLDVELGRTTCTKTQPNLDNCPFHDQPHLKRKAFCSFQIYAVPWQGTMTLSKSTCQDA |
| sequence length | 110,110,110,110 |
| structure length | 110,110,110,110 |
| publication title |
Domain swapping in N-truncated human cystatin C.
pubmed doi rcsb |
| molecule tags | Hydrolase inhibitor |
| molecule keywords | Cystatin C |
| source organism | Homo sapiens |
| pdb deposition date | 2003-10-06 |
| LinkProt deposition date | 2016-08-22 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| EFGH | PF00031 | Cystatin | Cystatin domain |
| EFGH | PF00031 | Cystatin | Cystatin domain |
| EFGH | PF00031 | Cystatin | Cystatin domain |
| EFGH | PF00031 | Cystatin | Cystatin domain |
Image from the rcsb pdb (www.rcsb.org)cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Alpha Beta | Roll | Nuclear Transport Factor 2; Chain: A, | Nuclear Transport Factor 2; Chain: A, | ||
| Alpha Beta | Roll | Nuclear Transport Factor 2; Chain: A, | Nuclear Transport Factor 2; Chain: A, | ||
| Alpha Beta | Roll | Nuclear Transport Factor 2; Chain: A, | Nuclear Transport Factor 2; Chain: A, | ||
| Alpha Beta | Roll | Nuclear Transport Factor 2; Chain: A, | Nuclear Transport Factor 2; Chain: A, |
#chains in the LinkProt database with same CATH superfamily 1R4C ACGH; 1R4C BCE; 1R4C ADEF; 1R4C ABEH; 1R4C EF; 1R4C ACDH; 1R4C BEG; 1R4C CDG; 1R4C BF; 1R4C ACDG; 1R4C CEGH; 1R4C BCEF; 1R4C BCF; 1R4C ABFG; 1R4C BCDG; 1R4C ACEH; 1R4C BC; 1R4C ADE; 1R4C AH; 1R4C CFGH; 1R4C AFG; 1R4C ADH; 1R4C FGH; 1R4C ABCD; 1R4C CDGH; 1R4C AEH; 1R4C BDG; 1R4C ABE; 1R4C FG; 1R4C BGH; 1R4C ABDE; 1R4C CEG; 1R4C ACF; 1R4C EGH; 1R4C BFH; 1R4C BEFH; 1R4C BCGH; 1R4C ACEF; 1R4C ABDH; 1R4C ADGH; 1R4C ABEF; 1R4C AC; 1R4C ACE; 1R4C ADEG; 1R4C DEG; 1R4C AFGH; 1R4C AE; 1R4C BCDH; 1R4C BG; 1R4C ABFH; 1R4C AD; 1R4C DFG; 1R4C BCG; 1R4C ACFH; 1R4C ACH; 1R4C BDH; 1R4C BCDF; 1R4C ADFG; 1R4C ADF; 1R4C ABF; 1R4C ABCE; 1R4C BDEG; 1R4C CDFG; 1R4C ABG; 1R4C AEG; 1R4C BDF; 1R4C ABCH; 1R4C AEFH; 1R4C BEGH; 1R4C DFGH; 1R4C AEFG; 1R4C BCFH; 1R4C BFGH; 1R4C ABCF; 1R4C CD; 1R4C CEFG; 1R4C AFH; 1R4C BCEH; 1R4C ADFH; 1R4C ACG; 1R4C ABDG; 1R4C FH; 1R4C BDEH; 1R4C BH; 1R4C ABEG; 1R4C ACD; 1R4C BD; 1R4C ACDE; 1R4C AG; 1R4C CGH; 1R4C BCFG; 1R4C CDEG; 1R4C BEFG; 1R4C EFH; 1R4C EFG; 1R4C BCD; 1R4C EG; 1R4C BCDE; 1R4C BEF; 1N9J AB; 1R4C EFGH; 1R4C ACDF; 1R4C ABD; 1R4C ADG; 1R4C AF; 1R4C AGH; 1R4C BDFG; 1R4C DG; 1R4C BDEF; 1R4C AEF; 1R4C BDE; 1R4C ABC; 1R4C BEH; 1R4C BDGH; 1R4C BFG; 1R4C BCEG; 1R4C AEGH; 1R4C ABH; 1R4C ABCG; 1R4C CG; 1R4C DEGH; 1R4C EH; 1R4C ACEG; 1R4C DGH; 1R4C ABDF; 1R4C BCH; 1R4C ADEH; 1R4C CFG; 1R4C ABGH; 1R4C GH; 1R4C BE; 1R4C AB; 1R4C BDFH; 1R4C ACFG; 1R4C DEFG; #chains in the LinkProt database with same CATH topology 1R4C ACGH; 1R4C BCE; 1R4C ADEF; 1R4C ABEH; 1R4C EF; 1R4C ACDH; 1R4C BEG; 1R4C CDG; 1R4C BF; 1R4C ACDG; 1R4C CEGH; 1R4C BCEF; 1R4C BCF; 1R4C ABFG; 1A2V ABE; 1R4C BCDG; 1R4C ACEH; 1R4C BC; 1R4C ADE; 1R4C AH; 1R4C CFGH; 1R4C AFG; 3DMC AB; 1R4C FGH; 1R4C ABCD; 1R4C CDGH; 1R4C AEH; 1R4C BDG; 1R4C ABE; 1A2V ABF; 1R4C FG; 1A2V CEF; 1R4C BGH; 1R4C ABDE; 1A2V EF; 1R4C CEG; 1R4C ACF; 1R4C EGH; 1A2V ABC; 1R4C BFH; 1R4C BEFH; 1R4C BCGH; 1R4C ACEF; 1R4C ABDH; 1R4C AE; 1R4C ADGH; 1R4C ABEF; 1R4C AC; 1R4C ACE; 1R4C ADEG; 1R4C DEG; 1R4C AFGH; 3ALA FG; 1R4C BCDH; 1R4C BG; 1R4C ABFH; 1R4C AD; 1R4C DFG; 1A2V BEF; 1R4C BCG; 1R4C ACFH; 1R4C ACH; 1A2V BCD; 1R4C BDH; 1R4C BCDF; 1R4C ADFG; 1R4C ADF; 1R4C ABF; 1R4C ABCE; 1R4C BDEG; 1R4C CDFG; 1R4C ABG; 1R4C AEG; 1R4C BDF; 1R4C ABCH; 1R4C AEFH; 1R4C BEGH; 1R4C DFGH; 1R4C AEFG; 1R4C BCFH; 1R4C BFGH; 1R4C ABCF; 1R4C CD; 1R4C CEFG; 1R4C AFH; 1R4C BCEH; 1R4C ADFH; 1R4C BCH; 1A2V AB; 1R4C ABDG; 1R4C BCFG; 1R4C BDEH; 1R4C BH; 1R4C ABEG; 1R4C ACD; 1R4C BD; 1R4C ACDE; 1R4C AG; 1R4C CGH; 1R4C FH; 1R4C CDEG; 1R4C BEFG; 1R4C EFH; 1A2V CD; 1R4C EFG; 1R4C BCD; 1A2V AEF; 1R4C EG; 1R4C BCDE; 1R4C BEF; 1N9J AB; 1R4C EFGH; 1R4C ACDF; 1R4C ABD; 1R4C ADG; 1R4C AF; 1R4C AGH; 1R4C BDFG; 1R4C DG; 1R4C BDEF; 1R4C AEF; 1R4C BDE; 1R4C ABC; 1R4C BEH; 1R4C BDGH; 1A2V ABD; 1R4C BFG; 1A2V CDE; 1R4C AEGH; 1R4C ABH; 1R4C ABCG; 1R4C CG; 1A2V DEF; 1R4C DEGH; 1R4C EH; 1A2V ACD; 1R4C ACEG; 1R4C ADH; 1A2V CDF; 1R4C BCEG; 1R4C DGH; 1R4C ABDF; 1R4C ACG; 1R4C ADEH; 1R4C CFG; 1R4C ABGH; 1R4C GH; 1R4C BE; 1R4C AB; 1R4C BDFH; 1R4C ACFG; 1R4C DEFG; #chains in the LinkProt database with same CATH homology 1R4C ACGH; 1R4C BCE; 1R4C ADEF; 1R4C ABEH; 1R4C EF; 1R4C ACDH; 1R4C BEG; 1R4C CDG; 1R4C BF; 1R4C ACDG; 1R4C CEGH; 1R4C BCEF; 1R4C BCF; 1R4C ABFG; 1A2V ABE; 1R4C BCDG; 1R4C ACEH; 1R4C BC; 1R4C ADE; 1R4C AH; 1R4C CFGH; 1R4C AFG; 3DMC AB; 1R4C FGH; 1R4C ABCD; 1R4C CDGH; 1R4C AEH; 1R4C BDG; 1R4C ABE; 1A2V ABF; 1R4C FG; 1A2V CEF; 1R4C BGH; 1R4C ABDE; 1A2V EF; 1R4C CEG; 1R4C ACF; 1R4C EGH; 1A2V ABC; 1R4C BFH; 1R4C BEFH; 1R4C BCGH; 1R4C ACEF; 1R4C ABDH; 1R4C AE; 1R4C ADGH; 1R4C ABEF; 1R4C AC; 1R4C ACE; 1R4C ADEG; 1R4C DEG; 1R4C AFGH; 3ALA FG; 1R4C BCDH; 1R4C BG; 1R4C ABFH; 1R4C AD; 1R4C DFG; 1A2V BEF; 1R4C BCG; 1R4C ACFH; 1R4C ACH; 1A2V BCD; 1R4C BDH; 1R4C BCDF; 1R4C ADFG; 1R4C ADF; 1R4C ABF; 1R4C ABCE; 1R4C BDEG; 1R4C CDFG; 1R4C ABG; 1R4C AEG; 1R4C BDF; 1R4C ABCH; 1R4C AEFH; 1R4C BEGH; 1R4C DFGH; 1R4C AEFG; 1R4C BCFH; 1R4C BFGH; 1R4C ABCF; 1R4C CD; 1R4C CEFG; 1R4C AFH; 1R4C BCEH; 1R4C ADFH; 1R4C BCH; 1A2V AB; 1R4C ABDG; 1R4C BCFG; 1R4C BDEH; 1R4C BH; 1R4C ABEG; 1R4C ACD; 1R4C BD; 1R4C ACDE; 1R4C AG; 1R4C CGH; 1R4C FH; 1R4C CDEG; 1R4C BEFG; 1R4C EFH; 1A2V CD; 1R4C EFG; 1R4C BCD; 1A2V AEF; 1R4C EG; 1R4C BCDE; 1R4C BEF; 1N9J AB; 1R4C EFGH; 1R4C ACDF; 1R4C ABD; 1R4C ADG; 1R4C AF; 1R4C AGH; 1R4C BDFG; 1R4C DG; 1R4C BDEF; 1R4C AEF; 1R4C BDE; 1R4C ABC; 1R4C BEH; 1R4C BDGH; 1A2V ABD; 1R4C BFG; 1A2V CDE; 1R4C AEGH; 1R4C ABH; 1R4C ABCG; 1R4C CG; 1A2V DEF; 1R4C DEGH; 1R4C EH; 1A2V ACD; 1R4C ACEG; 1R4C ADH; 1A2V CDF; 1R4C BCEG; 1R4C DGH; 1R4C ABDF; 1R4C ACG; 1R4C ADEH; 1R4C CFG; 1R4C ABGH; 1R4C GH; 1R4C BE; 1R4C AB; 1R4C BDFH; 1R4C ACFG; 1R4C DEFG;
#similar chains in the pdb database (40% sequence similarity)
3GAX_A; 3GAX_B; 3NX0_A; 3NX0_B; 1ROA_A; 1CEW_I; 3S67_A; 3QRD_A; 3QRD_B; 3QRD_C; 3QRD_D; 1R4C_A; 1R4C_B; 1R4C_C; 1R4C_D; 1R4C_F; 1R4C_G; 1R4C_H; 1RN7_A; 3PS8_A; 6ROA_A; 6ROA_B; 1G96_A; 1YVB_I; 3SVA_A; 1TIJ_A; 1TIJ_B; 6RPV_A; 1A90_A; 1A67_A; 3GAX_A; 3GAX_B; 3NX0_A; 3NX0_B; 1ROA_A; 1CEW_I; 3S67_A; 3QRD_A; 3QRD_B; 3QRD_C; 3QRD_D; 1R4C_A; 1R4C_B; 1R4C_C; 1R4C_D; 1R4C_E; 1R4C_G; 1R4C_H; 1RN7_A; 3PS8_A; 6ROA_A; 6ROA_B; 1G96_A; 1YVB_I; 3SVA_A; 1TIJ_A; 1TIJ_B; 6RPV_A; 1A90_A; 1A67_A; 3GAX_A; 3GAX_B; 3NX0_A; 3NX0_B; 1ROA_A; 1CEW_I; 3S67_A; 3QRD_A; 3QRD_B; 3QRD_C; 3QRD_D; 1R4C_A; 1R4C_B; 1R4C_C; 1R4C_D; 1R4C_E; 1R4C_F; 1R4C_H; 1RN7_A; 3PS8_A; 6ROA_A; 6ROA_B; 1G96_A; 1YVB_I; 3SVA_A; 1TIJ_A; 1TIJ_B; 6RPV_A; 1A90_A; 1A67_A; 3GAX_A; 3GAX_B; 3NX0_A; 3NX0_B; 1ROA_A; 1CEW_I; 3S67_A; 3QRD_A; 3QRD_B; 3QRD_C; 3QRD_D; 1R4C_A; 1R4C_B; 1R4C_C; 1R4C_D; 1R4C_E; 1R4C_F; 1R4C_G; 1RN7_A; 3PS8_A; 6ROA_A; 6ROA_B; 1G96_A; 1YVB_I; 3SVA_A; 1TIJ_A; 1TIJ_B; 6RPV_A; 1A90_A; 1A67_A;