| Link type | Probability | Chain A piercings | Chain B piercings | ||||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
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Unlink | 44% | -124B +200B | -10A +100A | ||||||||
Chain A Sequence |
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGIGGFINTKEYKNVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL |
Chain A Sequence |
PQFSLWKRPVVTAYIEGQPVEVLLDTGADDSIVAGIELGNNYSPKIVGGIGGFINTKEYKNVEIEVLNKKVRATIMTGDTPINIFGRNILTALGMSLNL |
| sequence length | 99,99 |
| structure length | 99,99 |
| publication title |
Structural evidence for effectiveness of darunavir and two related antiviral inhibitors against HIV-2 protease
pubmed doi rcsb |
| molecule tags | Hydrolase |
| molecule keywords | Protease |
| source organism | Human immunodeficiency virus type 2 (isolate rod) |
| ec nomenclature |
ec 2.7.7.49: RNA-directed DNA polymerase. ec 2.7.7.7: DNA-directed DNA polymerase. ec 3.1.13.2: Exoribonuclease H. ec 3.1.26.13: Retroviral ribonuclease H. ec 3.4.23.47: HIV-2 retropepsin. ec 2.7.7.49: RNA-directed DNA polymerase. ec 2.7.7.7: DNA-directed DNA polymerase. ec 3.1.13.2: Exoribonuclease H. ec 3.1.26.13: Retroviral ribonuclease H. ec 3.4.23.47: HIV-2 retropepsin. |
| pdb deposition date | 2008-08-28 |
| LinkProt deposition date | 2016-08-17 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| AB | PF00077 | RVP | Retroviral aspartyl protease |
| AB | PF00077 | RVP | Retroviral aspartyl protease |
Image from the rcsb pdb (www.rcsb.org)cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Beta Barrel | Cathepsin D, subunit A; domain 1 | Acid Proteases | ||
| Mainly Beta | Beta Barrel | Cathepsin D, subunit A; domain 1 | Acid Proteases |
#chains in the LinkProt database with same CATH superfamily 3HAU AB; 3EKX AB; 3GGV DGH; 1A8K BDE; 3FV3 EFN; 3GGA CD; 3EL1 AB; 3FV3 BDJ; 3GGX CDG; 1A94 BDE; 3GGX CGH; 3EM4 UV; 3FV3 AGI; 3FV3 CHK; 3EM4 AU; 3GGX AB; 3GGV ABH; 3GGX EF; 3DOX AQ; 3GGX ACD; 3FV3 DL; 3GGV ABE; 1A8K DE; 3GGX BCD; 3JW2 AB; 3ECG AB; 3FV3 BEM; 3EKP CD; 1A30 AC; 3GGV AB; 3EKT ABD; 3GGA CGH; 3GI0 AC; 3FV3 HNP; 3FV3 ADL; 3GI5 AB; 3GGA ABD; 3GGX FGH; 3IXO AB; 1AID AB; 3GGA BCD; 1A94 DE; 3EM4 AB; 3HAW AB; 3GGX ABG; 3EKQ AB; 3FV3 BGJ; 3GGV EFH; 3GGX ABH; 3GGV FGH; 3FV3 CIK; 3GGV CDE; 3HDK AB; 3FV3 DEF; 3GGX EFH; 3GGV GH; 3FV3 GO; 3GGX DEF; 3DOX APQ; 3GGX CEF; 3GGA CDG; 3FV3 CEF; 3GGA AGH; 3FV3 CK; 3FV3 DEL; 3FV3 EFH; 3GGX BEF; 3GGX CDF; 3GGV AGH; 3EM4 BUV; 3GGA AB; 3EKT AB; 1A94 ABD; 3FV3 CGO; 3FV3 BJL; 3FV3 EJM; 3EM6 AB; 3FV3 DLO; 3FV3 FHN; 3GGV ABD; 3GGA ACD; 3EKP BCD; 3FV3 CFK; 3FV3 ABJ; 3GGX AEF; 3FV3 BDL; 3GGX CDE; 3FV3 EHP; 3FV3 EMN; 3GGX EGH; 3GGV BCD; 3GGV DEF; 3JVY AB; 3GGV ABG; 3GI6 AB; 3FV3 GHO; 3EC0 AB; 3FV3 ACK; 3FV3 FIN; 3EKP ACD; 3GGX CDH; 3GGV GHI; 3GGX ABF; 3GGX DGH; 3GGV EFG; 3GGA CDH; 3FV3 DFL; 3EL9 AB; 1AJV AB; 3FV3 BJ; 3EL4 AB; 3FV3 FGN; 3EM3 AB; 3FV3 BCJ; 3EKY AB; 1A8K ADE; 3DOX AP; 3FV3 EM; 3FV3 BHJ; 3GGX AGH; 3GGX ABE; 3GGX BGH; 3GGX GH; 1A8K AB; 3FV3 CDK; 3FV3 AGO; 3GGU AB; 3HBO AB; 3FV3 AI; 1A94 AB; 3GGA GH; 3GGV CEF; 3FV3 DEM; 3GGV CDG; 3EMY AB; 3FV3 BHP; 3FV3 AEI; 3H5B AB; 3GGV EF; 3JVW AB; 3EKV AB; 3GI4 AB; 3GGV EGH; 3FV3 GHP; 3FV3 BFJ; 3GGV CD; 3FV3 BJO; 3EKT BCD; 3FV3 CKN; 3GGA BGH; 3GGV AEF; 3FV3 ADI; 3GGV ABC; 3DK1 AB; 3EM4 ABU; 3FX5 AB; 3EKP ABC; 3FV3 CHP; 3EL0 AB; 3GGA ABG; 3FV3 AEM; 3EM4 ABV; 3EKW AB; 3FV3 AFI; 3GGA DGH; 3FV3 DHL; 3GGV ABI; 1A94 ADE; 3GGV ABF; 3FV3 CEK; 3GGV CDH; 3FV3 EGO; 3GGV CDI; 3EKP ABD; 3FV3 EF; 3GGA ABH; 1A30 AB; 1A8K ABE; 3FV3 DGO; 3EKT ABC; 3GGV ACD; 3FV3 AFN; 3FV3 FGO; 3FV3 HP; 3FV3 BCK; 3FV3 AHI; 3GGV CGH; 3FV3 ACI; 3FV3 CFN; 3FV3 CKP; 1AJX AB; 3EKP AB; 3GGX ABD; 1A30 ABC; 3GGV EFI; 1AAQ AB; 3EKT CD; 3FV3 BGO; 3FV3 DGL; 3FV3 DFN; 1A30 BC; 3FV3 ABI; 3FV3 AHP; 1A9M AB; 3FV3 CEM; 3GGV CDF; 3EM4 AUV; 3GGV BGH; 1A8K ABD; 3FV3 BDG; 3GGA ABC; 3FV3 EGM; 3FV3 EHM; 3GGV BEF; 1A8G AB; 3GGX ABC; 3EKT ACD; 3FV3 ABG; 3GGX EFG; 3GGX CD; 3EL5 AB; 1A94 ABE; 3FV3 EFM; 3FV3 FN; #chains in the LinkProt database with same CATH topology 3HAU AB; 3EKX AB; 3GGV DGH; 1A8K BDE; 3FV3 EFN; 3GGA CD; 3EL1 AB; 3FV3 BDJ; 3GGX CDG; 1A94 BDE; 3GGX CGH; 3EM4 UV; 3FV3 AGI; 3FV3 CHK; 3EM4 AU; 3GGX AB; 3GGV ABH; 3GGX EF; 3DOX AQ; 3GGX ACD; 3FV3 DL; 3GGV ABE; 1A8K DE; 3GGX BCD; 3JW2 AB; 3ECG AB; 3FV3 BEM; 3EKP CD; 1A30 AC; 3GGV AB; 3EKT ABD; 3GGA CGH; 3GI0 AC; 3FV3 HNP; 3FV3 ADL; 3GI5 AB; 3GGA ABD; 3GGX FGH; 3IXO AB; 1AID AB; 3GGA BCD; 1A94 DE; 3EM4 AB; 3HAW AB; 3GGX ABG; 3EKQ AB; 3FV3 BGJ; 3GGV EFH; 3GGX ABH; 3GGV FGH; 3FV3 CIK; 3GGV CDE; 3HDK AB; 3FV3 DEF; 3GGX EFH; 3GGV GH; 3FV3 GO; 3GGX DEF; 3DOX APQ; 3GGX CEF; 3GGA CDG; 3FV3 CEF; 3GGA AGH; 3FV3 CK; 3FV3 DEL; 3FV3 EFH; 3GGX BEF; 3GGX CDF; 3GGV AGH; 3EM4 BUV; 3GGA AB; 3EKT AB; 1A94 ABD; 3FV3 CGO; 3FV3 BJL; 3FV3 EJM; 3EM6 AB; 3FV3 DLO; 3FV3 FHN; 3GGV ABD; 3GGA ACD; 3EKP BCD; 3FV3 CFK; 3FV3 ABJ; 3GGX AEF; 3FV3 BDL; 3GGX CDE; 3FV3 EHP; 3FV3 EMN; 3GGX EGH; 3GGV BCD; 3GGV DEF; 3JVY AB; 3GGV ABG; 3GI6 AB; 3FV3 GHO; 3EC0 AB; 3FV3 ACK; 3FV3 FIN; 3EKP ACD; 3GGX CDH; 3GGV GHI; 3GGX ABF; 3GGX DGH; 3GGV EFG; 3GGA CDH; 3FV3 DFL; 3EL9 AB; 1AJV AB; 3FV3 BJ; 3EL4 AB; 3FV3 FGN; 3EM3 AB; 3FV3 BCJ; 3EKY AB; 1A8K ADE; 3DOX AP; 3FV3 EM; 3FV3 BHJ; 3GGX AGH; 3GGX ABE; 3GGX BGH; 3GGX GH; 1A8K AB; 3FV3 CDK; 3FV3 AGO; 3GGU AB; 3HBO AB; 3FV3 AI; 1A94 AB; 3GGA GH; 3GGV CEF; 3FV3 DEM; 3GGV CDG; 3EMY AB; 3FV3 BHP; 3FV3 AEI; 3H5B AB; 3GGV EF; 3JVW AB; 3EKV AB; 3GI4 AB; 3GGV EGH; 3FV3 GHP; 3FV3 BFJ; 3GGV CD; 3FV3 BJO; 3EKT BCD; 3FV3 CKN; 3GGA BGH; 3GGV AEF; 3FV3 ADI; 3GGV ABC; 3DK1 AB; 3EM4 ABU; 3FX5 AB; 3EKP ABC; 3FV3 CHP; 3EL0 AB; 3GGA ABG; 3FV3 AEM; 3EM4 ABV; 3EKW AB; 3FV3 AFI; 3GGA DGH; 3FV3 DHL; 3GGV ABI; 1A94 ADE; 3GGV ABF; 3FV3 CEK; 3GGV CDH; 3FV3 EGO; 3GGV CDI; 3EKP ABD; 3FV3 EF; 3GGA ABH; 1A30 AB; 1A8K ABE; 3FV3 DGO; 3EKT ABC; 3GGV ACD; 3FV3 AFN; 3FV3 FGO; 3FV3 HP; 3FV3 BCK; 3FV3 AHI; 3GGV CGH; 3FV3 ACI; 3FV3 CFN; 3FV3 CKP; 1AJX AB; 3EKP AB; 3GGX ABD; 1A30 ABC; 3GGV EFI; 1AAQ AB; 3EKT CD; 3FV3 BGO; 3FV3 DGL; 3FV3 DFN; 1A30 BC; 3FV3 ABI; 3FV3 AHP; 1A9M AB; 3FV3 CEM; 3GGV CDF; 3EM4 AUV; 3GGV BGH; 1A8K ABD; 3FV3 BDG; 3GGA ABC; 3FV3 EGM; 3FV3 EHM; 3GGV BEF; 1A8G AB; 3GGX ABC; 3EKT ACD; 3FV3 ABG; 3GGX EFG; 3GGX CD; 3EL5 AB; 1A94 ABE; 3FV3 EFM; 3FV3 FN; #chains in the LinkProt database with same CATH homology 3HAU AB; 3EKX AB; 3GGV DGH; 1A8K BDE; 3FV3 EFN; 3GGA CD; 3EL1 AB; 3FV3 BDJ; 3GGX CDG; 1A94 BDE; 3GGX CGH; 3EM4 UV; 3FV3 AGI; 3FV3 CHK; 3EM4 AU; 3GGX AB; 3GGV ABH; 3GGX EF; 3DOX AQ; 3GGX ACD; 3FV3 DL; 3GGV ABE; 1A8K DE; 3GGX BCD; 3JW2 AB; 3ECG AB; 3FV3 BEM; 3EKP CD; 1A30 AC; 3GGV AB; 3EKT ABD; 3GGA CGH; 3GI0 AC; 3FV3 HNP; 3FV3 ADL; 3GI5 AB; 3GGA ABD; 3GGX FGH; 3IXO AB; 1AID AB; 3GGA BCD; 1A94 DE; 3EM4 AB; 3HAW AB; 3GGX ABG; 3EKQ AB; 3FV3 BGJ; 3GGV EFH; 3GGX ABH; 3GGV FGH; 3FV3 CIK; 3GGV CDE; 3HDK AB; 3FV3 DEF; 3GGX EFH; 3GGV GH; 3FV3 GO; 3GGX DEF; 3DOX APQ; 3GGX CEF; 3GGA CDG; 3FV3 CEF; 3GGA AGH; 3FV3 CK; 3FV3 DEL; 3FV3 EFH; 3GGX BEF; 3GGX CDF; 3GGV AGH; 3EM4 BUV; 3GGA AB; 3EKT AB; 1A94 ABD; 3FV3 CGO; 3FV3 BJL; 3FV3 EJM; 3EM6 AB; 3FV3 DLO; 3FV3 FHN; 3GGV ABD; 3GGA ACD; 3EKP BCD; 3FV3 CFK; 3FV3 ABJ; 3GGX AEF; 3FV3 BDL; 3GGX CDE; 3FV3 EHP; 3FV3 EMN; 3GGX EGH; 3GGV BCD; 3GGV DEF; 3JVY AB; 3GGV ABG; 3GI6 AB; 3FV3 GHO; 3EC0 AB; 3FV3 ACK; 3FV3 FIN; 3EKP ACD; 3GGX CDH; 3GGV GHI; 3GGX ABF; 3GGX DGH; 3GGV EFG; 3GGA CDH; 3FV3 DFL; 3EL9 AB; 1AJV AB; 3FV3 BJ; 3EL4 AB; 3FV3 FGN; 3EM3 AB; 3FV3 BCJ; 3EKY AB; 1A8K ADE; 3DOX AP; 3FV3 EM; 3FV3 BHJ; 3GGX AGH; 3GGX ABE; 3GGX BGH; 3GGX GH; 1A8K AB; 3FV3 CDK; 3FV3 AGO; 3GGU AB; 3HBO AB; 3FV3 AI; 1A94 AB; 3GGA GH; 3GGV CEF; 3FV3 DEM; 3GGV CDG; 3EMY AB; 3FV3 BHP; 3FV3 AEI; 3H5B AB; 3GGV EF; 3JVW AB; 3EKV AB; 3GI4 AB; 3GGV EGH; 3FV3 GHP; 3FV3 BFJ; 3GGV CD; 3FV3 BJO; 3EKT BCD; 3FV3 CKN; 3GGA BGH; 3GGV AEF; 3FV3 ADI; 3GGV ABC; 3DK1 AB; 3EM4 ABU; 3FX5 AB; 3EKP ABC; 3FV3 CHP; 3EL0 AB; 3GGA ABG; 3FV3 AEM; 3EM4 ABV; 3EKW AB; 3FV3 AFI; 3GGA DGH; 3FV3 DHL; 3GGV ABI; 1A94 ADE; 3GGV ABF; 3FV3 CEK; 3GGV CDH; 3FV3 EGO; 3GGV CDI; 3EKP ABD; 3FV3 EF; 3GGA ABH; 1A30 AB; 1A8K ABE; 3FV3 DGO; 3EKT ABC; 3GGV ACD; 3FV3 AFN; 3FV3 FGO; 3FV3 HP; 3FV3 BCK; 3FV3 AHI; 3GGV CGH; 3FV3 ACI; 3FV3 CFN; 3FV3 CKP; 1AJX AB; 3EKP AB; 3GGX ABD; 1A30 ABC; 3GGV EFI; 1AAQ AB; 3EKT CD; 3FV3 BGO; 3FV3 DGL; 3FV3 DFN; 1A30 BC; 3FV3 ABI; 3FV3 AHP; 1A9M AB; 3FV3 CEM; 3GGV CDF; 3EM4 AUV; 3GGV BGH; 1A8K ABD; 3FV3 BDG; 3GGA ABC; 3FV3 EGM; 3FV3 EHM; 3GGV BEF; 1A8G AB; 3GGX ABC; 3EKT ACD; 3FV3 ABG; 3GGX EFG; 3GGX CD; 3EL5 AB; 1A94 ABE; 3FV3 EFM; 3FV3 FN;
#similar chains in the LinkProt database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unlinked ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
