6WB8ABCD

Cryo-em structure of pkd2 c331s disease variant
A: 295-302,493-504 B: 295-302,493-504 C: 295-302,493-504 D: 295-302,493-504
Link type Probability Chain A piercings Chain B piercings Chain C piercings Chain D piercings
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
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Other Other 39% -694B -645C -661D -695A +261D +615D -659D +672D
Interpreting sequences
Chain A Sequence
YLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKM------EADNRSFIFYENLLLGVPRIRQLRVRNGSSSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEIL----------RSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQ
Chain A Sequence
YLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKM------EADNRSFIFYENLLLGVPRIRQLRVRNGSSSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEIL----------RSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQ
Chain A Sequence
YLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKM------EADNRSFIFYENLLLGVPRIRQLRVRNGSSSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEIL----------RSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQ
Chain A Sequence
YLKSVLRELVTYLLFLIVLCILTYGMMSSNVYYYTRMMSQLFLDTPVSKTEKTNFKTLSSMEDFWKFTEGSLLDGLYWKM------EADNRSFIFYENLLLGVPRIRQLRVRNGSSSIPQDLRDEIKECYDVYSVSSEDRAPFGPRNGTAWIYTSEKDLNGSSHWGIIATYSGAGYYLDLSRTREETAAQVASLKKNVWLDRGTRATFIDFSVYNANINLFCVVRLLVEFPATGGVIPSWQFQPLKLIRYVTTFDFFLAACEIIFCFFIFYYVVEEIL----------RSFWNCLDVVIVVLSVVAIGINIYRTSNVEVLLQFLEDQNTFPNFEHLAYWQIQFNNIAAVTVFFVWIKLFKFINFNRTMSQLSTTMSRCAKDLFGFAIMFFIIFLAYAQLAYLVFGTQVDDFSTFQECIFTQFRIILGDINFAEIEEANRVLGPIYFTTFVFFMFFILLNMFLAIINDTYSEVKSDLAQQ
sequence length 479,479,479,479
structure length 463,463,463,463
publication title Molecular dysregulation of ciliary polycystin-2 channels caused by variants in the TOP domain.
pubmed doi rcsb
molecule tags Transport protein
molecule keywords Polycystin-2
source organism Homo sapiens
missing residues A: 295-302,493-504 B: 295-302,493-504 C: 295-302,493-504 D: 295-302,493-504
pdb deposition date2020-03-26
LinkProt deposition date2021-05-04

pfam database annotations

chain Pfam Accession CodePfam Family IdentifierPfam Description
ABCD PF08016 PKD_channelPolycystin cation channel
ABCD PF08016 PKD_channelPolycystin cation channel
ABCD PF08016 PKD_channelPolycystin cation channel
ABCD PF08016 PKD_channelPolycystin cation channel
Image from the rcsb pdb (www.rcsb.org)
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LinkProt | Interdisciplinary Laboratory of Biological Systems Modelling