6UVAEGNR

Cryoem structure of the active adrenomedullin 2 receptor g protein complex with adrenomedullin 2 peptide
R: 54-64,106-110,323-329,354-362
Link type Probability Chain E piercings Chain G piercings Chain N piercings Chain R piercings
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
view details
Other Other 36% -63G -144N +47N -88N +229N -247N +284N -376N -383N -144R
Interpreting sequences
Chain E Sequence
MLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKR
Chain E Sequence
KLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFR
Chain E Sequence
QVQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASISYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQGTQVTV
Chain E Sequence
GVTRNKIMTAQYECYQKIMQ---------YCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICD---NWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVT-----NLYMKAVRATLILVPLLGIEFVLIPW-------EEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQY
sequence length 111,49,126,368
structure length 111,49,126,344
publication title Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
pubmed doi rcsb
molecule tags Membrane protein
molecule keywords Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
source organism Homo sapiens
missing residues R: 54-64,106-110,323-329,354-362
pdb deposition date2019-11-01
LinkProt deposition date2021-04-30

pfam database annotations

chain Pfam Accession CodePfam Family IdentifierPfam Description
EGNR PF04901 RAMPReceptor activity modifying family
EGNR PF00631 G-gammaGGL domain
EGNR PF00002 7tm_27 transmembrane receptor (Secretin family)
EGNR PF02793 HRMHormone receptor domain
Image from the rcsb pdb (www.rcsb.org)
...loading similar chains, please wait...

...loading similar chains in PDB, please wait...


 
#similar chains in the LinkProt database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unlinked
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

LinkProt | Interdisciplinary Laboratory of Biological Systems Modelling