6UVABNPR

Cryoem structure of the active adrenomedullin 2 receptor g protein complex with adrenomedullin 2 peptide
R: 54-64,106-110,323-329,354-362
Link type Probability Chain B piercings Chain N piercings Chain P piercings Chain R piercings
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
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Other Other 41% -8N +18N -32N +70N -80N -341P -403P -11R +271R -340R
Interpreting sequences
Chain B Sequence
DQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Chain B Sequence
QVQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASISYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQGTQVTV
Chain B Sequence
LLRVGCVLGTCQVQNLSHRLWQLMGPAGRQDSAPVDPSSPHSY
Chain B Sequence
GVTRNKIMTAQYECYQKIMQ---------YCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICD---NWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVT-----NLYMKAVRATLILVPLLGIEFVLIPW-------EEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQY
sequence length 336,126,43,368
structure length 336,126,43,344
publication title Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
pubmed doi rcsb
molecule tags Membrane protein
molecule keywords Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
source organism Homo sapiens
missing residues R: 54-64,106-110,323-329,354-362
pdb deposition date2019-11-01
LinkProt deposition date2021-04-30

pfam database annotations

chain Pfam Accession CodePfam Family IdentifierPfam Description
BNPR PF00400 WD40WD domain, G-beta repeat
BNPR PF00002 7tm_27 transmembrane receptor (Secretin family)
BNPR PF02793 HRMHormone receptor domain
Image from the rcsb pdb (www.rcsb.org)
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LinkProt | Interdisciplinary Laboratory of Biological Systems Modelling