6UVABGPR

Cryoem structure of the active adrenomedullin 2 receptor g protein complex with adrenomedullin 2 peptide
R: 54-64,106-110,323-329,354-362
Link type Probability Chain B piercings Chain G piercings Chain P piercings Chain R piercings
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
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Other Other 38% -63G -38P -159P -340P +357P -402P -340R -341R
Interpreting sequences
Chain B Sequence
DQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Chain B Sequence
KLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFR
Chain B Sequence
LLRVGCVLGTCQVQNLSHRLWQLMGPAGRQDSAPVDPSSPHSY
Chain B Sequence
GVTRNKIMTAQYECYQKIMQ---------YCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICD---NWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVT-----NLYMKAVRATLILVPLLGIEFVLIPW-------EEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQY
sequence length 336,49,43,368
structure length 336,49,43,344
publication title Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
pubmed doi rcsb
molecule tags Membrane protein
molecule keywords Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
source organism Homo sapiens
missing residues R: 54-64,106-110,323-329,354-362
pdb deposition date2019-11-01
LinkProt deposition date2021-04-30

pfam database annotations

chain Pfam Accession CodePfam Family IdentifierPfam Description
BGPR PF00400 WD40WD domain, G-beta repeat
BGPR PF00631 G-gammaGGL domain
BGPR PF00002 7tm_27 transmembrane receptor (Secretin family)
BGPR PF02793 HRMHormone receptor domain
Image from the rcsb pdb (www.rcsb.org)
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LinkProt | Interdisciplinary Laboratory of Biological Systems Modelling