6UVABENR

Cryoem structure of the active adrenomedullin 2 receptor g protein complex with adrenomedullin 2 peptide
R: 54-64,106-110,323-329,354-362
Link type Probability Chain B piercings Chain E piercings Chain N piercings Chain R piercings
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
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Other Other 31% +262N -274N +127R +270B +127B +144E +46R -156R +226R -247R +284R -400R -403R
Interpreting sequences
Chain B Sequence
DQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Chain B Sequence
MLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKR
Chain B Sequence
QVQLQESGGGLVQPGGSLRLSCAASGFTFSNYKMNWVRQAPGKGLEWVSDISQSGASISYTGSVKGRFTISRDNAKNTLYLQMNSLKPEDTAVYYCARCPAPFTRDCFDVTSTTYAYRGQGTQVTV
Chain B Sequence
GVTRNKIMTAQYECYQKIMQ---------YCNRTWDGWLCWNDVAAGTESMQLCPDYFQDFDPSEKVTKICD---NWFRHPASNRTWTNYTQCNVNTHEKVKTALNLFYLTIIGHGLSIASLLISLGIFFYFKSLSCQRITLHKNLFFSFVCNSVVTIIHLTAVANNQALVATNPVSCKVSQFIHLYLMGCNYFWMLCEGIYLHTLIVVAVFAEKQHLMWYYFLGWGFPLIPACIHAIARSLYYNDNCWISSDTHLLYIIHGPICAALLVNLFFLLNIVRVLITKLKVT-----NLYMKAVRATLILVPLLGIEFVLIPW-------EEVYDYIMHILMHFQGLLVSTIFCFFNGEVQAILRRNWNQY
sequence length 336,111,126,368
structure length 336,111,126,344
publication title Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
pubmed doi rcsb
molecule tags Membrane protein
molecule keywords Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
source organism Homo sapiens
missing residues R: 54-64,106-110,323-329,354-362
pdb deposition date2019-11-01
LinkProt deposition date2021-04-30

pfam database annotations

chain Pfam Accession CodePfam Family IdentifierPfam Description
BENR PF00400 WD40WD domain, G-beta repeat
BENR PF04901 RAMPReceptor activity modifying family
BENR PF00002 7tm_27 transmembrane receptor (Secretin family)
BENR PF02793 HRMHormone receptor domain
Image from the rcsb pdb (www.rcsb.org)
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LinkProt | Interdisciplinary Laboratory of Biological Systems Modelling