6UVABEGP

Cryoem structure of the active adrenomedullin 2 receptor g protein complex with adrenomedullin 2 peptide
Link type Probability Chain B piercings Chain E piercings Chain G piercings Chain P piercings
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
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Other Other 30% +143E +143E +266G +340G -63P -104B -149B +180B -48G -340P -29P
Interpreting sequences
Chain B Sequence
DQLRQEAEQLKNQIRDARKACADATLSQITNNIDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFLDDNQIVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN
Chain B Sequence
MLERLPLCGKAFADMMGKVDVWKWCNLSEFIVYYESFTNCTEMEANVVGCYWPNPLAQGFITGIHRQFFSNCTVDRVHLEDPPDEVLIPLIVIPVVLTVAMAGLVVWRSKR
Chain B Sequence
KLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFR
Chain B Sequence
LLRVGCVLGTCQVQNLSHRLWQLMGPAGRQDSAPVDPSSPHSY
sequence length 336,111,49,43
structure length 336,111,49,43
publication title Structure and Dynamics of Adrenomedullin Receptors AM1and AM2Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.
pubmed doi rcsb
molecule tags Membrane protein
molecule keywords Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
source organism Homo sapiens
pdb deposition date2019-11-01
LinkProt deposition date2021-04-30

pfam database annotations

chain Pfam Accession CodePfam Family IdentifierPfam Description
BEGP PF00400 WD40WD domain, G-beta repeat
BEGP PF04901 RAMPReceptor activity modifying family
BEGP PF00631 G-gammaGGL domain
Image from the rcsb pdb (www.rcsb.org)
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LinkProt | Interdisciplinary Laboratory of Biological Systems Modelling