| Link type | Probability | Loop ranges | Chain A piercings | Chain B piercings | Chain C piercings | Chain D piercings | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
|
Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
| view details |
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Other | 35% | -A | +503C +503C +385D +478D | +80B -400B +411B -504B | ||||||||||
Chain A Sequence |
SLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNS---------DSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQA |
Chain A Sequence |
SLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSD-------QDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQA |
Chain A Sequence |
KSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNG-AGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAE |
Chain A Sequence |
KSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSD-------QDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREA |
| sequence length | 475,475,477,474 |
| structure length | 466,468,476,467 |
| publication title |
Structure-Based Design of Inhibitors with Improved Selectivity for Steroidogenic Cytochrome P450 17A1 over Cytochrome P450 21A2.
pubmed doi rcsb |
| molecule tags | Oxidoreductase/oxidoreductase inhibitor |
| molecule keywords | Steroid 17-alpha-hydroxylase/17,20 lyase |
| source organism | Homo sapiens |
| missing residues | A: 273-283 B: 274-282 C: 276-278 D: 274-282 |
| pdb deposition date | 2018-02-22 |
| LinkProt deposition date | 2018-06-21 |
Image from the rcsb pdb (www.rcsb.org)#similar chains in the LinkProt database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unlinked ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
