5NX1ABCD

Combinatorial engineering of proteolytically resistant appi variants that selectively inhibit human kallikrein 6 for cancer therapy
A: 36-38,67-69,125-127,130-132,147-150,203-208,220-222
Link type Probability Loop ranges Chain A piercings Chain B piercings Chain C piercings Chain D piercings
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Other Other 34% -A +54A -245A
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Interpreting sequences
Chain A Sequence
LVHGGPCDKTSHPYQAALYTS-GHLLCGGVLIHPLWVLTAAHCKKPNLQVFL-GKHNLGQQESSQEQSSVVRAVIHPDYDAASHDQDIMLLRLARPAKLSELIQPLPLER-DCSA-QTTSCHILGWGKTADG--DFPDTIQCAYIHLVSREECEHAYPGQITQNMLCAGDEKYGKDSCQGDSGGPLVC----GDHLRGLVSWGNI-PCGSKEKPGVYTNVCRYTNWIQKTIQA
Chain A Sequence
EVCSEQAETGPCR
Chain A Sequence
EVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCG
Chain A Sequence
AMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGS
sequence length 222,13,54,42
structure length 222,13,54,42
publication title Combinatorial Engineering of Proteolytically Resistant APPI Variants that Selectively Inhibit Human Kallikrein 6 for Cancer Therapy
rcsb
molecule tags Hydrolase
molecule keywords Kallikrein-6
source organism Homo sapiens
missing residues A: 36-38,67-69,125-127,130-132,147-150,203-208,220-222
pdb deposition date2017-05-09
LinkProt deposition date2018-06-03
Image from the rcsb pdb (www.rcsb.org)
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LinkProt | Interdisciplinary Laboratory of Biological Systems Modelling