5GNMABCD

Cytochrome p450 vdh (cyp107br1) l348m mutant
Link type Probability Chain A piercings Chain B piercings Chain C piercings Chain D piercings
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
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Other Other 39% +403D +366A +121C -142C +243C -280C -337C +353C -380C +392C -403C -401D -62A -404A -402B -402B
Interpreting sequences
Chain A Sequence
LTTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHTLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEIADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGVPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDEDGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVFFGHGIHFCMGAQLARLEGRVAIGRLFADRPELALAVGLDELVYRESTLVRGLSRMPVTMGPR
Chain A Sequence
LTTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHTLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEIADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGVPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDEDGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVFFGHGIHFCMGAQLARLEGRVAIGRLFADRPELALAVGLDELVYRESTLVRGLSRMPVTMGPR
Chain A Sequence
LTTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHTLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEIADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGVPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDEDGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVFFGHGIHFCMGAQLARLEGRVAIGRLFADRPELALAVGLDELVYRESTLVRGLSRMPVTMGPRSA
Chain A Sequence
LTTTGTEQHDLFSGTFWQNPHPAYAALRAEDPVRKLALPDGPVWLLTRYADVREAFVDPRLSKDWRHTLPEDQRADMPATPTPMMILMDPPDHTRLRKLVGRSFTVRRMNELEPRITEIADGLLAGLPTDGPVDLMREYAFQIPVQVICELLGVPAEDRDDFSAWSSVLVDDSPADDKNAAMGKLHGYLSDLLERKRTEPDDALLSSLLAVSDEDGDRLSQEELVAMAMLLLIAGHETTVNLIGNGVLALLTHPDQRKLLAEDPSLISSAVEEFLRFDSPVSQAPIRFTAEDVTYSGVTIPAGEMVMLGLAAANRDADWMPEPDRLDITRDASGGVFFGHGIHFCMGAQLARLEGRVAIGRLFADRPELALAVGLDELVYRESTLVRGLSRMPVTMGPRSA
sequence length 399,399,401,401
structure length 399,399,401,401
publication title Structural insights into the mechanism of the drastic changes in enzymatic activity of the cytochrome P450 vitamin D3 hydroxylase (CYP107BR1) caused by a mutation distant from the active site
pubmed doi rcsb
molecule tags Oxidoreductase
molecule keywords Vitamin D(3) 25-hydroxylase
source organism Pseudonocardia autotrophica
pdb deposition date2016-07-22
LinkProt deposition date2017-05-19
Image from the rcsb pdb (www.rcsb.org)
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LinkProt | Interdisciplinary Laboratory of Biological Systems Modelling