5GJQIKUn

Structure of the human 26s proteasome bound to usp14-ubal
I: 84-91 U: 142-152
Link type Probability Chain I piercings Chain K piercings Chain U piercings Chain n piercings
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Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
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Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
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Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
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Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
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Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
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Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
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Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
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Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
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Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
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Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
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Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
view details
Other Other 31% -285K -317K -419K -419K -258U -429U -429U -429U -296n -430I -75K +419K
Interpreting sequences
Chain I Sequence
LERIKDYLLMEEEFIRNQEQ------KQEEERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYK
Chain I Sequence
DLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
Chain I Sequence
LAVQKVVVHPLVLLSVVDHFNRIGKVGNQKRVVGVLLGSWQKKVLDVSNSFAVPFDEDDKDDSVWFLDHDYLENMYGMFKKVNARERIVGWYHTGPKLHKNDIAINELMKRYCPNSVLVIIDVKPKDLGLPTEAYISVE---------SKTFEHVTSEIGAEEAEEVGVEHLLRDIKDTTVGTLSQRITNQVHGLKGLNSKLLDIRSYLEKVATGKLPINHQIIYQLQDVFNLLPDVSLQEFVKAFYLKTNDQMVVVYLASLIRSVVALHNLINNKIANRDAEKKEGQEKEE
Chain I Sequence
IGTGYDLSASTFSPDGRVFQVEYAMKAVENSSTAIGIRCKDGVVFGVEKLVLSKLYEEGSNKRLFNVDRHVGMAVAGLLADARSLADIAREEASNFRSNFGYNIPLKHLADRVAMYVHAYTLYSAVRPFGCSFMLGSYSVNDGAQLYMIDPSGVSYGYWGCAIGKARQAAKTEIEKLQMKEMTCRDIVKEVAKIIYIVHDEVKDKAFELELSWVGELTNGRHEIVPKDIREEAEKYAKESLKE
sequence length 365,380,292,243
structure length 359,380,283,243
publication title An atomic structure of the human 26S proteasome.
pubmed doi rcsb
molecule tags Hydrolase
molecule keywords Proteasome subunit beta type-6
source organism Homo sapiens
missing residues I: 84-91 U: 142-152
ec nomenclature ec 3.4.25.1: Proteasome endopeptidase complex.
pdb deposition date2016-07-01
LinkProt deposition date2016-09-22

pfam database annotations

chain Pfam Accession CodePfam Family IdentifierPfam Description
IKUn PF00004 AAAATPase family associated with various cellular activities (AAA)
IKUn PF00004 AAAATPase family associated with various cellular activities (AAA)
IKUn PF01398 JABJAB1/Mov34/MPN/PAD-1 ubiquitin protease
IKUn PF13012 MitMem_regMaintenance of mitochondrial structure and function
IKUn PF00227 ProteasomeProteasome subunit
IKUn PF10584 Proteasome_A_NProteasome subunit A N-terminal signature
Image from the rcsb pdb (www.rcsb.org)
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LinkProt | Interdisciplinary Laboratory of Biological Systems Modelling