5EKVABCD

Co-crystal structure of eif4e with nucleotide mimetic inhibitor.
A: 205-211 C: 204-213
Link type Probability Chain A piercings Chain B piercings Chain C piercings Chain D piercings
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
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Other Other 57% +53B +140C -181D -217A
Interpreting sequences
Chain A Sequence
PEHYIKHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTAT-----TKNRFVV
Chain A Sequence
RIIYDRKFLMECRN
Chain A Sequence
KHPLQNRWALWFFKNDKSKTWQANLRLISKFDTVEDFWALYNHIQLSSNLMPGCDYSLFKDGIEPMWEDEKNKRGGRWLITLNKQQRRSDLDRFWLETLLCLIGESFDDYSDDVCGAVVNVRAKGDKIAIWTTECENREAVTHIGRVYKERLGLPPKIVIGYQSHADTA--------NRFVV
Chain A Sequence
RIIYDRKFLMECRN
sequence length 187,14,182,14
structure length 182,14,174,14
publication title Design of nucleotide-mimetic and non-nucleotide inhibitors of the translation initiation factor eIF4E: Synthesis, structural and functional characterisation
doi rcsb
molecule tags Translation
molecule keywords Eukaryotic translation initiation factor 4E
source organism Homo sapiens
missing residues A: 205-211 C: 204-213
pdb deposition date2015-11-04
LinkProt deposition date2016-09-12
Image from the rcsb pdb (www.rcsb.org)
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LinkProt | Interdisciplinary Laboratory of Biological Systems Modelling